Ignite Creation Date:
2024-05-06 @ 8:06 PM
Last Modification Date:
2024-10-26 @ 3:20 PM
Study NCT ID:
NCT06256198
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-02-13
First Post:
2024-01-31
Brief Title:
Role of PCO2 Gap as Predictor of Clinical Outcome in ICU Septic Patients
Sponsor:
Ain Shams University
Organization:
Ain Shams University
Study Overview
Official Title:
Comparison Between PCO2 Gap Lactate and Procalcitonin as Predictors of Clinical Outcome in ICU Septic Patients
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PCO2
Brief Summary:
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection if not recognized early and managed promptly it can lead to septic shock multiple organ failure and death Sepsis is associated with high mortality and the early recognition of the signs of tissue hypo perfusion is crucial in its management
This prospective study was aimed to detect that PCO2 gap can be taken as a reliable prognostic tool in septic patients
This prospective study was aimed to detect that PCO2 gap can be taken as a reliable prognostic tool in septic patients
Detailed Description:
In the community setting sepsis often presents as the clinical deterioration of common and preventable infections Sepsis also frequently results from infections acquired in health care settings which are one of the most frequent adverse events during care delivery and affect hundreds of millions of patients worldwide every year The venous-to-arterial carbon dioxide difference Pv-aCO2 can indicate the adequacy of microvascular blood flow in the early phases of resuscitation in sepsis Hence other resuscitation goals such as PCO2 gap have been suggested due to their ability to predict adverse clinical outcomes and simplicity in patients achieving normal oxygen-derived parameters during the early phases of resuscitation in septic shock
Blood lactate level is also useful in evaluating sepsis Serum lactate is a good indicator of the presence of hypoxic tissue during septic shock since its production takes place during Anerobic metabolism
Procalcitonin PCT is the precursor of calcitonin and higher levels are associated with the development of sepsis Commonly there is an elevation of PCT levels 4 h after the onset of symptoms peaking between 8 h and 24 h
Blood lactate level is also useful in evaluating sepsis Serum lactate is a good indicator of the presence of hypoxic tissue during septic shock since its production takes place during Anerobic metabolism
Procalcitonin PCT is the precursor of calcitonin and higher levels are associated with the development of sepsis Commonly there is an elevation of PCT levels 4 h after the onset of symptoms peaking between 8 h and 24 h
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None