Ignite Creation Date:
2024-05-06 @ 8:06 PM
Last Modification Date:
2024-10-26 @ 3:20 PM
Study NCT ID:
NCT06257290
Status:
RECRUITING
Last Update Posted:
2024-03-04
First Post:
2024-02-06
Brief Title:
The Role of Platelet TLRs in Platelet Activation During VTE
Sponsor:
Centre Hospitalier Universitaire de Saint Etienne
Organization:
Centre Hospitalier Universitaire de Saint Etienne
Study Overview
Official Title:
The Role of Platelet TLRs in Platelet Activation During VTE
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ROT-PLAT-VTE
Brief Summary:
Venous thromboembolic disease VTE is a frequent and potentially serious pathology Therapeutic management has improved considerably over the last few decades enabling the application of codified management in line with the recently updated French management recommendations
One of the main remaining difficulties concerns VTE sequelae mainly post-thrombotic syndrome after deep vein thrombosis and post-pulmonary embolism syndrome after pulmonary embolism The mechanisms leading to the absence of complete repermeabilization of vessels affected by Venous thromboembolic disease VTE are still poorly understood
The concept of immunothrombosis closely associating immunity inflammation and thrombosis could in part explain the appearance of these sequelae Platelets appear to play a key role in the onset of sequelae Platelets are known to be involved both in the onset of a VTE episode and in the inflammatory response This involvement is illustrated by the expression of inflammatory receptors such as TLR toll-like receptor 2 and TLR4
Th aim to investigate the role of platelets in the occurrence of sequelae mainly via their role in the inflammatory response in Venous thromboembolic disease VTE patients
One of the main remaining difficulties concerns VTE sequelae mainly post-thrombotic syndrome after deep vein thrombosis and post-pulmonary embolism syndrome after pulmonary embolism The mechanisms leading to the absence of complete repermeabilization of vessels affected by Venous thromboembolic disease VTE are still poorly understood
The concept of immunothrombosis closely associating immunity inflammation and thrombosis could in part explain the appearance of these sequelae Platelets appear to play a key role in the onset of sequelae Platelets are known to be involved both in the onset of a VTE episode and in the inflammatory response This involvement is illustrated by the expression of inflammatory receptors such as TLR toll-like receptor 2 and TLR4
Th aim to investigate the role of platelets in the occurrence of sequelae mainly via their role in the inflammatory response in Venous thromboembolic disease VTE patients
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2023-A00448-37 | OTHER | ANSM | None |