Ignite Creation Date:
2024-05-06 @ 8:06 PM
Last Modification Date:
2024-10-26 @ 3:20 PM
Study NCT ID:
NCT06256471
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-02-13
First Post:
2024-02-05
Brief Title:
The Impact of Parasitic Infection on Multiple Sclerosis and Nephrotic Syndrome
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
The Impact of Parasitic Infection on the Course of Multiple Sclerosis and Nephrotic Syndrome
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1 Detection of the prevalence of parasitic infections amoung patients with multiple sclerosis and nephrotic syndrome at Assiut University Hospitals
2 Detection of the effect of parasitic infections on these diseases courses
3 Inform authorities about the importance of management of parasitic infections in those patients
2 Detection of the effect of parasitic infections on these diseases courses
3 Inform authorities about the importance of management of parasitic infections in those patients
Detailed Description:
Parasitic protozoal infections have prominent immunomodulatory changes in different autoimmune diseases Moreover helminths and their derivatives were established to have a protective role Clinical trials of autoimmune diseases have tested the obvious helminths immunomodulatory effect in inflammatory bowel disease multiple sclerosis and rheumatoid arthritis Autoimmunity is the immune systems inability to differentiate between foreign and self-antigens resulting in damage of the healthy tissues Recently strong epidemiological studies revealed a steady increase in autoimmune diseases incidence in the developed countries Also The prevalence of the autoimmune diseases varies between rural and urban areas within the same country The high records of autoimmune diseases incidences in these countries is attributed to the decline in infectious diseases prevalence hygiene hypothesis
Multiple sclerosis MS is an inflammatory demyelinating disease affecting the CNS Although its etiology remains obscure several lines of evidence show that autoimmunity has a major role in the disease pathogenesis Recent researches explain that parasitic infections can alter the disease course Which is in the form of decreased number of relapses minimal change in disability scores and lower MRI activity
Childhood nephrotic syndrome NS is a worldwide disease with incidence and prognosis vary greatly according to the geographic distribution with a prevalence of 15 per 100 000 under 16 years of age and higher incidence in South Asian Pakistani Indian and Bangladeshi and Arab children NS is considered as a disease with immune impairment Also some infections are found to be related to nephrotic syndrome Parasitic infections may possibly be nonspecific triggers of NS For instance parasitic infections have been known to be associated with immune complex- mediated glomerular lesions Moreover parasites can mediate Altered T-helper cell cytokine expression binding of autoantibodies to glomerular autoantigens and immune complex formation
The present study clarifies two very interesting and yet unexplored potentials Do parasitic infections aggravate or ameliorate the course of autoimmune diseases Also what is the prevalence of parasitic infections in MS and NS in our governorate
Multiple sclerosis MS is an inflammatory demyelinating disease affecting the CNS Although its etiology remains obscure several lines of evidence show that autoimmunity has a major role in the disease pathogenesis Recent researches explain that parasitic infections can alter the disease course Which is in the form of decreased number of relapses minimal change in disability scores and lower MRI activity
Childhood nephrotic syndrome NS is a worldwide disease with incidence and prognosis vary greatly according to the geographic distribution with a prevalence of 15 per 100 000 under 16 years of age and higher incidence in South Asian Pakistani Indian and Bangladeshi and Arab children NS is considered as a disease with immune impairment Also some infections are found to be related to nephrotic syndrome Parasitic infections may possibly be nonspecific triggers of NS For instance parasitic infections have been known to be associated with immune complex- mediated glomerular lesions Moreover parasites can mediate Altered T-helper cell cytokine expression binding of autoantibodies to glomerular autoantigens and immune complex formation
The present study clarifies two very interesting and yet unexplored potentials Do parasitic infections aggravate or ameliorate the course of autoimmune diseases Also what is the prevalence of parasitic infections in MS and NS in our governorate
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None