Ignite Creation Date:
2024-05-06 @ 8:05 PM
Last Modification Date:
2024-10-26 @ 3:20 PM
Study NCT ID:
NCT06258252
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-14
First Post:
2024-02-05
Brief Title:
Effect of Metabolic Dysfunction in Branched-chain Amino Acids on Cardiac Function in Patients With Sepsis
Sponsor:
West China Hospital
Organization:
West China Hospital
Study Overview
Official Title:
Effect of Metabolic Dysfunction in Branched-chain Amino Acids on Cardiac Function in Patients With Sepsis an Observational Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The current project was designed to examine the effects of BCAA metabolic dysfunction on cardiac function in septic patients
Detailed Description:
Patients with sepsis and withwithout type 2 diabetes will be included Patients prospectively collected the following indicators in the intensive care unit 1 myocardial injury-related biomarkers troponin T and B natriuretic peptide levels 2 cardiac structure-related indicators the size of the left and right ventricle left ventricular ejection fraction etc3 septic cardiomyopathy incidence Troponin T001ngml is the standard for the diagnosis of septic cardiomyopathy Additionally the investigators will collect the peripheral blood at preoperative day 1 day 3 and day 5 after surgery Peripheral blood plasma and PBMCs were separated by differential centrifugation the concentration of BCAAs in serum and PBMCs the expression of PBMCs BCAAs metabolic enzymes BCAT 1 BCKDH and PP 2 Cm by WB and the levels of AST ALT LDH CK and CK-MB
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None