Ignite Creation Date:
2024-05-06 @ 8:04 PM
Last Modification Date:
2024-10-26 @ 3:20 PM
Study NCT ID:
NCT06240806
Status:
COMPLETED
Last Update Posted:
2024-02-05
First Post:
2024-01-14
Brief Title:
Efficacy of Manuka Honey Oral Rinse in Treatment of Xerostomia
Sponsor:
British University In Egypt
Organization:
British University In Egypt
Study Overview
Official Title:
Efficacy of Manuka Honey Oral Rinse in Treatment of Xerostomia in Elderly A Randomized Controlled Clinical Trial
Status:
COMPLETED
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Xerostomia causes many clinical problems including oral infections speech difficulties and impaired chewing and swallowing of food thus may affect the individuals quality of life therefore this study aimed to evaluate the clinical effectiveness of Manuka honey mouth rinse using the subjective dry mouth score and patient satisfaction as primary objectives and to assess the effect of Manuka honey on the salivary flow rate and objective dry mouth score as secondary objectives
Detailed Description:
Xerostomia has a variety of possible etiological factors it is generally classified as having primary and secondary causes Primary causes comprise conditions that directly affect the salivary glands and induce xerostomia like Sjogrens syndrome diabetes mellitus type 1 and 2 thyroid disease adrenal pathology renal or hepatic diseases hepatitis C virus infection and HIV disease
Secondary causes of xerostomia include the side-effects of radiation therapy or chemotherapy rheumatoid arthritis scleroderma mixed connective tissues diseases systemic lupus erythematous graft versus host disease anorexia alcohol and smoking and commonly prescribed drugs 500 medications reportedly cause dry mouth The most common medications causing hyposalivation are those with anticholinergic activity sympathomimetic and benzodiazepines The risk of xerostomia increases with the synergistic effects of xerogenic medications multiple medications higher doses of medication and the duration of the medication
Honey was found to have several benefits as an alternative medicine it has been used as a natural medicine for more than 2000 years mainly for wound healing Though there are many varieties of honey only some of them eg Manuka honey and Malaysian Tualang honey have been studied in detail for their medicinal properties
Manuka honey is a monofloral honey produced from the nectar of flowers of Manuka tree This variety is produced from the Apis mellifera honey bees using New Zealand Manuka plants producing specific floral-variety named as Leptospermum scoparium The composition of Manuka honey consists of carbohydrates minerals proteins fatty acids phenolic and flavonoid compounds Although such compounds are found in other types of honey other unique features also occur in Manuka honey such as an unusually high level of methylglyoxal MGO formed from dihydroxyacetone DHA which correlates with antibacterial activityManuka honey shows antioxidant and anticancer properties which are considered due to its constituents-phytochemicals working as active bio-compounds
Secondary causes of xerostomia include the side-effects of radiation therapy or chemotherapy rheumatoid arthritis scleroderma mixed connective tissues diseases systemic lupus erythematous graft versus host disease anorexia alcohol and smoking and commonly prescribed drugs 500 medications reportedly cause dry mouth The most common medications causing hyposalivation are those with anticholinergic activity sympathomimetic and benzodiazepines The risk of xerostomia increases with the synergistic effects of xerogenic medications multiple medications higher doses of medication and the duration of the medication
Honey was found to have several benefits as an alternative medicine it has been used as a natural medicine for more than 2000 years mainly for wound healing Though there are many varieties of honey only some of them eg Manuka honey and Malaysian Tualang honey have been studied in detail for their medicinal properties
Manuka honey is a monofloral honey produced from the nectar of flowers of Manuka tree This variety is produced from the Apis mellifera honey bees using New Zealand Manuka plants producing specific floral-variety named as Leptospermum scoparium The composition of Manuka honey consists of carbohydrates minerals proteins fatty acids phenolic and flavonoid compounds Although such compounds are found in other types of honey other unique features also occur in Manuka honey such as an unusually high level of methylglyoxal MGO formed from dihydroxyacetone DHA which correlates with antibacterial activityManuka honey shows antioxidant and anticancer properties which are considered due to its constituents-phytochemicals working as active bio-compounds
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None