Ignite Creation Date:
2024-05-06 @ 8:04 PM
Last Modification Date:
2024-10-26 @ 3:20 PM
Study NCT ID:
NCT06242496
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-02-05
First Post:
2024-01-29
Brief Title:
Brain Abscesses in Transplant Recipients a Multicentre Retrospective Study BAT-STUDY
Sponsor:
Assistance Publique - Hôpitaux de Paris
Organization:
Assistance Publique - Hôpitaux de Paris
Study Overview
Official Title:
Brain Abscesses in Transplant Recipients a Multicentre Retrospective Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Allotransplantation is the process of transferring organs tissues or cells from a healthy donor to a recipient The two main applications of allotransplantation are solid organ transplantation and allogeneic hematopoietic stem cell transplantation For several reasons including the need to use immunosuppressive drugs after transplantation recipients of allografts carry a high risk of infectious complications
Central nervous system infections are dreadful complications of transplantation which can be divided into brain abscesses meningitis and encephalitis In particular brain abscesses pose major diagnostic and therapeutic challenges to transplant physicians and are frequently fatal in transplant recipients As compared with immunocompetent patients transplant recipients and other immunocompromised patients have an increased risk of brain abscesses due to opportunistic pathogens including fungi parasites bacteria and mycobacteria
Determining the epidemiology of brain abscesses is critical to guide transplant teams regarding the diagnosis and management of brain abscesses in transplant recipients
Because the incidence of brain abscesses is low after transplantation transplant teams often have limited clinical experience in the management of these infections Similarly most publications focusing on post-transplant brain abscesses are either case reports small case series or review articles
We therefore aim to conduct a multicentre retrospective study on the epidemiology the characteristics and the outcome of brain abscesses in transplant recipients in the era of new diagnostic tools and progress in prophylaxis
Central nervous system infections are dreadful complications of transplantation which can be divided into brain abscesses meningitis and encephalitis In particular brain abscesses pose major diagnostic and therapeutic challenges to transplant physicians and are frequently fatal in transplant recipients As compared with immunocompetent patients transplant recipients and other immunocompromised patients have an increased risk of brain abscesses due to opportunistic pathogens including fungi parasites bacteria and mycobacteria
Determining the epidemiology of brain abscesses is critical to guide transplant teams regarding the diagnosis and management of brain abscesses in transplant recipients
Because the incidence of brain abscesses is low after transplantation transplant teams often have limited clinical experience in the management of these infections Similarly most publications focusing on post-transplant brain abscesses are either case reports small case series or review articles
We therefore aim to conduct a multicentre retrospective study on the epidemiology the characteristics and the outcome of brain abscesses in transplant recipients in the era of new diagnostic tools and progress in prophylaxis
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None