Ignite Creation Date:
2024-05-06 @ 8:04 PM
Last Modification Date:
2024-10-26 @ 3:20 PM
Study NCT ID:
NCT06244355
Status:
RECRUITING
Last Update Posted:
2024-03-29
First Post:
2023-10-27
Brief Title:
Studies of Phenotypic and Functional Characteristics of Circulating Neutrophil Subpopulations in Patients With Lung Cancer
Sponsor:
Assistance Publique - Hôpitaux de Paris
Organization:
Assistance Publique - Hôpitaux de Paris
Study Overview
Official Title:
Studies of Phenotypic and Functional Characteristics of Circulating Neutrophil Subpopulations in Patients With Lung Cancer Undergoing Treatment
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PNN-CP
Brief Summary:
The objective is to study the phenotypic functional and metabolomic characteristics of neutrophils circulating subpopulations in lung cancer patients and to compare them to a control group of healthy volunteers A blood sample will be taken before the first treatment session for the lung cancer patient and a second blood sample will be taken during the first evaluation visit
The investigators hypothesize that there may be different circulating neutrophil subpopulations in patients with metastatic non-small cell lung cancer NSCLC involved in tumor progression and resistance to immunotherapy
The investigators hypothesize that there may be different circulating neutrophil subpopulations in patients with metastatic non-small cell lung cancer NSCLC involved in tumor progression and resistance to immunotherapy
Detailed Description:
Immune checkpoint inhibitors ICI have been shown to be effective in metastatic lung cancer Unfortunately 80 of patients do not respond and show rapid disease progression Identifying predictive biomarkers of response is essential for early adaptation of management Circulating lymphocytes and neutrophils represent a biomarker NLR predictive of immunotherapy response in particular via the measurement of the neutrophils lymphocyte ratio Some preclinical work suggests a role for circulating neutrophil subpopulations like MDSC myeloid derived suppressor cells in ICI resistance Certain circulating neutrophil subpopulations are thought to promote tumor progression angiogenesis and metastasis with immunosuppressive activity Identifying these pro-tumor subpopulations could predict the response to ICI and could be a potential therapeutic target Our goal is to characterize the circulating neutrophil subpopulations of lung cancer patients and correlate these characteristics with response and survival phenotypically and functionally
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2021-A01939-32 | OTHER | France ANSM | None |