Ignite Creation Date:
2024-05-06 @ 8:04 PM
Last Modification Date:
2024-10-26 @ 3:19 PM
Study NCT ID:
NCT06233695
Status:
COMPLETED
Last Update Posted:
2024-02-26
First Post:
2024-01-13
Brief Title:
Gender-based Differences in the Outcome of Treatment With Aldosterone Antagonists in Patients With Heart Failure
Sponsor:
Alexandria University
Organization:
Alexandria University
Study Overview
Official Title:
The Gender-Based Differences in the Outcome of Treatment by Aldosterone Antagonists in Patients With Heart Failure
Status:
COMPLETED
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
GBDAL-HF
Brief Summary:
Heart failure HF is a major healthcare problem In patients with Heart Failure with Reduced Ejection Fraction HFrEF aldosterone antagonists reduce mortality and hospitalization rate Gender-related differences have been described in the regulation of renin angiotensin aldosterone system RAAS which is at the core of the pathophysiology of HF Regarding gender-related differences in the use of MRAs less is known about the effects of androgens on RAAS
In this single-center prospective cohort a total of 100 adult 18 years ambulatory patients of both sexes with the diagnosis of HF with HFrEF LVEF 40 and NYHA class II-IV under optimized medical therapy started an aldosterone antagonist are enrolled and followed-up for 6 months Patients are categorized according to their apparent sexual gender into two groups the male group and the female group
In this single-center prospective cohort a total of 100 adult 18 years ambulatory patients of both sexes with the diagnosis of HF with HFrEF LVEF 40 and NYHA class II-IV under optimized medical therapy started an aldosterone antagonist are enrolled and followed-up for 6 months Patients are categorized according to their apparent sexual gender into two groups the male group and the female group
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None