Ignite Creation Date:
2024-05-06 @ 8:03 PM
Last Modification Date:
2024-10-26 @ 3:19 PM
Study NCT ID:
NCT06237478
Status:
COMPLETED
Last Update Posted:
2024-02-01
First Post:
2024-01-23
Brief Title:
Effects of Glycopyrrolate on Heart Rate and Heart Rate Variability in Patients With Different Basic Heart Rate
Sponsor:
Zhuan Zhang
Organization:
Yangzhou University
Study Overview
Official Title:
Effects of Glycopyrrolate on Heart Rate and Heart Rate Variability in Patients With Different Basic Heart Rate
Status:
COMPLETED
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Glycopyrrolate is an anticholinergic medication commonly used in respiratory medicine for treating chronic obstructive pulmonary disease COPD bronchial asthma and other conditions In the perioperative period it is often administered before anesthesia to reduce secretions in the salivary glands bronchi and pharynx It is used during the recovery period to counteract the muscarinic effects of anticholinesterase inhibitors and can also be employed to preventtreat vagal reflexes and related arrhythmias induced by surgery or medications
Heart rate HR is influenced by both the sympathetic and parasympathetic nervous systems The baseline HR of different patients may vary due to differing levels of sympathetic and parasympathetic nerve activity within the body It remains unclear whether patients with different baseline HRs exhibit varying degrees of HR elevation after the administration of glycopyrrolateiethe parasympathetic activity in vivo is antagonized The primary aim of this study is to explore the impact of glycopyrrolate administration on HR in patients with different baseline HRs The secondary objective is to investigate the effects of glycopyrrolate on heart rate variability HRV in patients with different baseline HR
Heart rate HR is influenced by both the sympathetic and parasympathetic nervous systems The baseline HR of different patients may vary due to differing levels of sympathetic and parasympathetic nerve activity within the body It remains unclear whether patients with different baseline HRs exhibit varying degrees of HR elevation after the administration of glycopyrrolateiethe parasympathetic activity in vivo is antagonized The primary aim of this study is to explore the impact of glycopyrrolate administration on HR in patients with different baseline HRs The secondary objective is to investigate the effects of glycopyrrolate on heart rate variability HRV in patients with different baseline HR
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None