Ignite Creation Date:
2024-05-06 @ 8:03 PM
Last Modification Date:
2024-10-26 @ 3:19 PM
Study NCT ID:
NCT06237075
Status:
RECRUITING
Last Update Posted:
2024-02-01
First Post:
2024-01-15
Brief Title:
Combining fMRI and tDCS in Neuropathic Pain
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
Combining Functional Magnetic Resonance Imaging and Transcranial Direct Current Stimulation to Investigate Pain-related Brain Networks in Patients With Neuropathic Pain
Status:
RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The proposed project aims to explore possible neuromodulatory effects of transcranial direct current stimulation tDCS on neuropathic pain caused by peripheral neuropathy tDCS will be performed through an MRI-compatible stimulation setting during functional magnetic resonance imaging fMRI scanning The stimulation target of tDCS will be the primary motor cortex M1 and the dorsolateral prefrontal cortex DLPFC We expect that results from the current project will advance the understanding of neuromodulatory mechanisms of tDCS and facilitate the development of treatment strategies for patients with neuropathic pain
Detailed Description:
Neuropathic pain is the most excruciating symptom in peripheral neuropathy such as diabetic or chemotherapy-induced neuropathy Management of neuropathic pain is a challenging clinical problem because only less than 50 patients are responsive to pharmacological treatment Neuropathic pain is naturally considered as a direct consequence of peripheral nerve injury that induces hypersensitivity or ectopic activities in nociceptive nerve terminals Nevertheless maladaptive changes in the pain-related networks of the brain also play a crucial role in the generation amplification and drug-resistance of neuropathic pain The proposed project aims to explore possible neuromodulatory effects of transcranial direct current stimulation tDCS on neuropathic pain caused by peripheral neuropathy tDCS is a non-invasive stimulation technique that delivers a low-intensity current into the brain to modulate the synaptic plasticity of cortical neurons To investigate the instantaneous effects of tDCS tDCS will be performed through an MRI-compatible stimulation setting during functional magnetic resonance imaging fMRI scanning The stimulation target of tDCS will be the primary motor cortex M1 and the dorsolateral prefrontal cortex DLPFC This simultaneous tDCS-fMRI approach will enable us to 1 identify the neural substrates of neuropathic pain that could be modulated by neurostimulation 2 to characterize the spatial patterns of functional hemodynamic brain responses following tDCS and 3 to assess changes in cortical excitability and neuroplasticity associated with pain perception after non-invasive brain stimulation We expect that results from the current project will advance the understanding of neuromodulatory mechanisms of tDCS and facilitate the development of treatment strategies for patients with neuropathic pain
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None