Ignite Creation Date:
2024-05-06 @ 8:03 PM
Last Modification Date:
2024-10-26 @ 3:19 PM
Study NCT ID:
NCT06231251
Status:
RECRUITING
Last Update Posted:
2024-01-30
First Post:
2022-06-30
Brief Title:
Endoscopic Gastric Reduction of Gastric Mucosa in Obesity
Sponsor:
Zagazig University
Organization:
Zagazig University
Study Overview
Official Title:
Impact of Endoscopic Gastric Reduction of Ghrelin Receptors Rich Gastric Mucosa on Obesity and Metabolic Syndrome a Randomized Controlled Trial
Status:
RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ETO
Brief Summary:
In the stomach the ghrelin-containing cells are more abundant in the fundus than in the pylorus originally termed XA-like cells These XA-like cells account for approximately 20 of the endocrine cell population in adult oxyntic glands
Ghrelin enhances the secretion of growth hormone the stimulation of appetite and food intake the modulation of gastric acid secretion motility and the endocrine and exocrine pancreatic secretions
Ghrelin enhances the secretion of growth hormone the stimulation of appetite and food intake the modulation of gastric acid secretion motility and the endocrine and exocrine pancreatic secretions
Detailed Description:
Ghrelin is 28 amino acid peptide hormone approximately 70 of circulating ghrelin is secreted by the stomach with most of the remainder originating in duodenum jejunum and ileum Lower amount of secretion outside the gut including hypothalamus arcuate nucleus and paraventricular nucleus pituitary lung adrenal cortex kidney bone testis placenta and pancreatic islet cells Ghrelin enhances the secretion of growth hormone the stimulation of appetite and food intake the modulation of gastric acid secretion motility and the endocrine and exocrine pancreatic secretions Synthetic ghrelin imitative was shown to increase fat deposition and appetite through an action at the level of the hypothalamus arcuate nucleus mainly the orexigenic neuropeptide Y NPY neurons
Alterations of ghrelin play an important role in appetite fluctuation following meals The secretion of ghrelin by the stomach depends largely on the nutritional state Ghrelin levels show pre-prandial increases and postprandial decreases
Low systemic ghrelin levels have been reported in untreated hyperthyroidism in male hypogonadism in the polycystic ovary syndrome or after total gastrectomy 5 6
Alterations of ghrelin play an important role in appetite fluctuation following meals The secretion of ghrelin by the stomach depends largely on the nutritional state Ghrelin levels show pre-prandial increases and postprandial decreases
Low systemic ghrelin levels have been reported in untreated hyperthyroidism in male hypogonadism in the polycystic ovary syndrome or after total gastrectomy 5 6
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None