Ignite Creation Date:
2024-05-05 @ 6:58 PM
Last Modification Date:
2024-10-26 @ 9:40 AM
Study NCT ID:
NCT00585442
Status:
TERMINATED
Last Update Posted:
2016-05-27
First Post:
2007-12-22
Brief Title:
Effects of Vitamin D on Renin Expression in Hypertensive Patients
Sponsor:
University of Utah
Organization:
University of Utah
Study Overview
Official Title:
Effects of Calcitriol 1α 25-OH2 Vitamin D3 on Renin Expression in Hypertensive Patients Without Vitamin D Deficiency
Status:
TERMINATED
Status Verified Date:
2016-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Lack of quality data
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The cardiovascular effects of vitamin D therapy in humans have been documented only in patients with known vitamin D deficiency or hyperparathyroidism a surrogate marker of inadequate vitamin D activity It is unknown whether the cardiovascular benefits of vitamin D therapy extend beyond these patients to the general hypertensive population We propose to directly measure the effect of vitamin D therapy on plasma renin activity PRA plasma renin concentration PRC renin transcription in mononuclear leukocytes and blood pressure in hypertensive but otherwise healthy patients in a randomized controlled experimental trial This will be the first study to assess vitamin D receptor VDR biological PRA PRC renin mRNA and polymorphisms and hypertensive activity in patients without vitamin D deficiency We hypothesize that vitamin D inhibition of renin transcription will produce significant reductions in PRA PRC renin transcription inflammatory cytokines SBP and DBP with potential variation by VDR genotype Such a result may prove to be significant in the treatment of hypertension as even modest blood pressure reductions 5 mmHg are associated with a 14 reduction in mortality due to stroke a 9 reduction in mortality due to CHD and a 7 overall reduction in all-cause mortality
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 10151812 | OTHER_GRANT | American Foundation for Pharmaceutical Education | None |