Ignite Creation Date:
2024-05-06 @ 8:02 PM
Last Modification Date:
2024-10-26 @ 3:19 PM
Study NCT ID:
NCT06232005
Status:
COMPLETED
Last Update Posted:
2024-01-30
First Post:
2024-01-22
Brief Title:
Intralesional Injection of Mitomycin C Following Visual Internal Urethrotomy for Recurrent Urethral Stricture
Sponsor:
Ain Shams University
Organization:
Ain Shams University
Study Overview
Official Title:
Intralesional Injection of Mitomycin C Following Visual Internal Urethrotomy for Recurrent Urethral Stricture
Status:
COMPLETED
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To evaluate the effectiveness of administering mitomycin C through intralesional injection after performing visual internal urethrotomy VIU for the treatment of recurring urethral stricture
Detailed Description:
Numerous studies have investigated the impact of intralesional administration of antifibrotic drugs on urethral strictures following visual internal urethrotomy VIU These drugs include mitomycin C botulinum toxin A somatostatin analog and glucocorticoids Mitomycin C MMC is known for its potent chemotherapeutic and antibiotic properties It effectively hinders mitosis and fibroblast proliferation playing a crucial role in tissue healing and scar formation by reducing the release of matrix proteins through the inhibition of proliferative fibroblasts With its anti-proliferative and anti-scarring characteristics MMC proves to be a suitable option for treating recurrent urethral strictures
thus we conduct a randomized controlled trial to evaluate the safety and efficacy of Mitomycin in decrease urethral stricture recurrence
thus we conduct a randomized controlled trial to evaluate the safety and efficacy of Mitomycin in decrease urethral stricture recurrence
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None