Ignite Creation Date:
2024-05-06 @ 8:02 PM
Last Modification Date:
2024-10-26 @ 3:19 PM
Study NCT ID:
NCT06232785
Status:
COMPLETED
Last Update Posted:
2024-01-31
First Post:
2024-01-07
Brief Title:
Gynecologic Endoscopic Surgery of Female Motion Sickness Patients
Sponsor:
Second Hospital of Jilin University
Organization:
Second Hospital of Jilin University
Study Overview
Official Title:
Application of Remifentanil Target Controlled Infusion Combined With Ibuprofen Injection in Gynecologic Endoscopic Surgery of Female Motion Sickness Patients
Status:
COMPLETED
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this clinical trial is to compare the analgesic effect of sufentanil and ibuprofen and the incidence of vomiting and to choose better postoperative analgesic drugs for motion sickness patientsin describe participant population The main questions it aims to answer are
Whether this anesthesia method can meet the analgesic needs of gynecological laparoscopic surgery
Whether this anesthesia method can reduce the incidence of nausea and vomiting in patients with motion sickness after gynecological laparoscopic surgery
Participants will use target-controlled infusion anesthesia combined with 08g ibuprofen injection
Researchers will compare with use of target-controlled infusion combined with sufentanil to see if the incidence of nausea and vomiting is higher
Whether this anesthesia method can meet the analgesic needs of gynecological laparoscopic surgery
Whether this anesthesia method can reduce the incidence of nausea and vomiting in patients with motion sickness after gynecological laparoscopic surgery
Participants will use target-controlled infusion anesthesia combined with 08g ibuprofen injection
Researchers will compare with use of target-controlled infusion combined with sufentanil to see if the incidence of nausea and vomiting is higher
Detailed Description:
Abstract Objective To compare the analgesic effect of sufentanil and ibuprofen and the incidence of vomiting and to choose better postoperative analgesic drugs for motion sickness patients Methods Sixty-eight female patients aged between 18 and 60 years with motion sickness were selected for gynecologic endoscopic surgery under general anesthesia Sixty-eight female patients were randomly divided into two groups Group B ibuprofen group and Group S sufentanil group using a random number table method The initial plasma target concentration of propofol was set at 4ugml and adjusted using the titration method Once the patient lost consciousness the target concentration of remifentanil was set at 4ngml and rocuronium at 06mgkg followed by endotracheal intubation three minutes later During the operation the plasma target concentration of propofol was maintained at 5ugml and remifentanil at 4ngml with adjustments made based on stress reaction levels General anesthesia was sustained through continuous administration of rocuronium at doses of 5 µgkgmin In Group B ibuprofen group intravenous administration of ibuprofen 08g took place within half an hour before the end of surgery in Group S sufentanil group intravenous injection of sufentanil 02ugkg occurred half an hour before completion of the operation along with intravenous injection of dexamethasone 5mg five minutes prior to anesthesia induction to prevent postoperative nausea and vomiting in both groups The following data were collected duration of operation pneumoperitoneum time extubation time respiratory recovery time Incidence of postoperative nausea and vomiting at different time intervals Postanesthesia care unit residence period T1 0-3h after extubation T2 3-6h after extubation T3 6-12h after extubation T4 12-24h after extubation T5 Visual analogue pain score Postanesthesia care unit residence period T1 0-3h after extubation T2 3-6h after extubation T3 6-12h after extubation T4 12-24h after extubation T5 Frequency of use of analgesics and antiemetic drugs Incidence of adverse reactions within 24 hours after surgery Postoperative satisfaction
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None