Ignite Creation Date:
2024-05-05 @ 9:53 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00006073
Status:
TERMINATED
Last Update Posted:
2017-10-06
First Post:
2000-07-25
Brief Title:
Endocrine Studies in Health and Disease
Sponsor:
Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Endocrine Studies in Health and Disease
Status:
TERMINATED
Status Verified Date:
2016-08-31
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will evaluate healthy normal volunteers and patients with a variety of endocrine disorders to 1 learn more about conditions that affect the endocrine glands glands that secrete hormones and 2 train physicians in endocrinology
Patients with endocrine-related conditions and healthy volunteers of all ages may be eligible for this study
All participants will have a physical examination medical and history They may be required to provide blood saliva or urine samples and undergo ultrasound using sound waves or magnetic resonance using a magnetic field imaging to visualize internal body structures
Some healthy adult volunteers will have hormone-stimulating tests to assess endocrine function These tests measure blood hormone levels before and after injection of a synthetic form of a hormone A device called a heparin lock through which the hormone is injected and the blood samples are collected is placed in a vein in the arm or hand Blood samples are drawn before the hormone is injected and at various intervals after the injection to measure levels of the hormone These tests which last from 1 to 3 hours may include the following
1 CRH stimulation test corticotropin-releasing hormone is given to test pituitary and adrenal gland function
2 ACTH stimulation test adrenocorticotrophic hormone is given to test adrenal gland function
3 LHRH stimulation test luteinizing hormone-releasing hormone is given to test pituitary gland function
4 TRH stimulation test thyroid-releasing hormone is given to test pituitary and thyroid gland function
5 GHRH stimulation test growth hormone releasing hormone is given to measure growth hormone levels
An oral glucose tolerance test which is similar to the stimulation tests may also be done to measure blood glucose sugar and insulin levels after drinking a sugary liquid
Healthy volunteers and patients with a hereditary endocrine disorder and their family members may also be asked to provide a blood sample for genetic studies of inherited endocrine disorders Patients with endocrine-related disorders may be offered medical or surgical treatment for their disorder
AcAccess httpturnersnichdnihgov for additional study publications
Patients with endocrine-related conditions and healthy volunteers of all ages may be eligible for this study
All participants will have a physical examination medical and history They may be required to provide blood saliva or urine samples and undergo ultrasound using sound waves or magnetic resonance using a magnetic field imaging to visualize internal body structures
Some healthy adult volunteers will have hormone-stimulating tests to assess endocrine function These tests measure blood hormone levels before and after injection of a synthetic form of a hormone A device called a heparin lock through which the hormone is injected and the blood samples are collected is placed in a vein in the arm or hand Blood samples are drawn before the hormone is injected and at various intervals after the injection to measure levels of the hormone These tests which last from 1 to 3 hours may include the following
1 CRH stimulation test corticotropin-releasing hormone is given to test pituitary and adrenal gland function
2 ACTH stimulation test adrenocorticotrophic hormone is given to test adrenal gland function
3 LHRH stimulation test luteinizing hormone-releasing hormone is given to test pituitary gland function
4 TRH stimulation test thyroid-releasing hormone is given to test pituitary and thyroid gland function
5 GHRH stimulation test growth hormone releasing hormone is given to measure growth hormone levels
An oral glucose tolerance test which is similar to the stimulation tests may also be done to measure blood glucose sugar and insulin levels after drinking a sugary liquid
Healthy volunteers and patients with a hereditary endocrine disorder and their family members may also be asked to provide a blood sample for genetic studies of inherited endocrine disorders Patients with endocrine-related disorders may be offered medical or surgical treatment for their disorder
AcAccess httpturnersnichdnihgov for additional study publications
Detailed Description:
This protocol is designed to allow endocrine-related evaluations of healthy subjects and patients with a variety of endocrine disorders Healthy subjects may be studied to obtain normative data for endocrine tests involving blood urine saliva ultrasound and magnetic resonance examinations If not eligible for a specific NICHD research protocol patients with endocrine-related conditions may be evaluated under the auspices of this protocol to advance the clinical skills of physicians participating in NICHD clinical research and training programs and to provide stimuli for new clinical research initiatives Standard medically-indicated laboratory or radiological studies may be performed to confirm a diagnosis or to aid in the management of the patient In some cases the patient will receive medical or surgical treatment for their disorder according to current clinical practice The overall purpose of endocrine evaluations under this protocol is to support our clinical training and research missions
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 00-CH-0180 | None | None | None |