Ignite Creation Date:
2024-05-06 @ 8:01 PM
Last Modification Date:
2024-10-26 @ 3:18 PM
Study NCT ID:
NCT06220994
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2024-01-24
First Post:
2023-02-15
Brief Title:
the Gut Microbiome and Metabolomics in Chronic Lower extreMities Threatening Ischemia
Sponsor:
Beijing Tsinghua Chang Gung Hospital
Organization:
Beijing Tsinghua Chang Gung Hospital
Study Overview
Official Title:
The Gut Microbiome and Metabolomics Among Chronic Lower Extremities Threatening Ischemia Patients in China - a Prospective Observational Study
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2023-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MMM
Brief Summary:
Intestinal floras and their metabolites are involved in progressing metabolic and cardiovascular diseases However currently articles related to the relationship between intestinal floras and atherosclerosis mainly focus on coronary atherosclerotic disease CAD population or atherosclerosis model animals such as ApoE-- LDLR-- high-fat diet mice and there are few studies on Chronic limb-threatening ischemia CLTI CLTI and CAD have a similar pathological basis of atherosclerosis It is unclear whether intestinal flora plays an essential role in the occurrence and development of CLTI This project aims to explore the relation between microorganisms metabolites and CLTI
Detailed Description:
This project aims to study the intestinal flora and its metabolites in patients with CLTI explore whether CLTI patients and CAD patients have their own characteristic flora analyze the microorganisms and metabolites markers of poor prognosis in patients with CLTI and screen out the key differential bacteria and metabolites that inhibit the progress of CLTI in order to provide new insights and research basis for the treatment of CLTI
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None