Ignite Creation Date:
2024-05-06 @ 8:00 PM
Last Modification Date:
2024-10-26 @ 3:18 PM
Study NCT ID:
NCT06211985
Status:
COMPLETED
Last Update Posted:
2024-05-30
First Post:
2023-12-23
Brief Title:
Copeptin Disease Severity Indicator
Sponsor:
Berker Okay
Organization:
Haseki Training and Research Hospital
Study Overview
Official Title:
Copeptın as a Dısease Severıty Indıcator A Prospectıve Case-Control Study
Status:
COMPLETED
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Copeptin serves as a biomarker emanating from the pituitary gland functioning as the precursor to arginine vasopressin AVP Its role in the regulation of endothelial dysfunction inflammation and water-electrolyte balance has been established The measurement of AVP levels poses challenges due to its brief half-life and the intricate nature of its detection method In contrast copeptin provides an indirect means of gauging circulating AVP levels as it can be conveniently assessed through a sandwich immunoassay As a neuroendocrine stress hormone copeptin emerges as a prognostic indicator reflective of an individuals stress burden Moreover its applicability extends to various acute conditions such as ischemic stroke or myocardial infarction Notably copeptin proves to be a dependable tool in the differential diagnosis of diverse ailments characterized by polyuria and polydipsia
Lower respiratory tract infection LRTI stands as the predominant cause of morbidity and mortality among children and adolescents globally Notably copeptin has demonstrated utility in forecasting the severity and complications associated with severe pneumonia in adults While early investigations into copeptins role in pediatric LRTI suggest its potential for diagnosing pneumonia and predicting complications the outcomes of these studies present conflicting results
Although there has been a notable increase in studies on copeptin in pediatric patients over the past decade research specifically exploring its correlation with pneumonia remains scarce This prospective case-control study is designed to investigate the potential association between copeptin levels and the severity of illness in pediatric patients with pneumonia The study aims to determine whether copeptin levels can serve as a reliable predictor of disease severity in pneumonia offering valuable insights for clinical application The outcomes of this research may contribute significantly to our comprehension of copeptins role in disease prognosis and management thereby facilitating the development of more efficacious diagnostic and therapeutic approaches Additionally the study seeks to identify the factors influencing copeptin levels and establish a cut-off value for copeptin in pediatric patients diagnosed with pneumonia
Lower respiratory tract infection LRTI stands as the predominant cause of morbidity and mortality among children and adolescents globally Notably copeptin has demonstrated utility in forecasting the severity and complications associated with severe pneumonia in adults While early investigations into copeptins role in pediatric LRTI suggest its potential for diagnosing pneumonia and predicting complications the outcomes of these studies present conflicting results
Although there has been a notable increase in studies on copeptin in pediatric patients over the past decade research specifically exploring its correlation with pneumonia remains scarce This prospective case-control study is designed to investigate the potential association between copeptin levels and the severity of illness in pediatric patients with pneumonia The study aims to determine whether copeptin levels can serve as a reliable predictor of disease severity in pneumonia offering valuable insights for clinical application The outcomes of this research may contribute significantly to our comprehension of copeptins role in disease prognosis and management thereby facilitating the development of more efficacious diagnostic and therapeutic approaches Additionally the study seeks to identify the factors influencing copeptin levels and establish a cut-off value for copeptin in pediatric patients diagnosed with pneumonia
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None