Ignite Creation Date:
2024-05-05 @ 6:58 PM
Last Modification Date:
2024-10-26 @ 9:38 AM
Study NCT ID:
NCT00574340
Status:
COMPLETED
Last Update Posted:
2019-09-12
First Post:
2007-12-13
Brief Title:
Metabolic Causes of Thrombosis in Type 2 Diabetes - Question 4
Sponsor:
University of Maryland Baltimore
Organization:
University of Maryland Baltimore
Study Overview
Official Title:
SCCOR in Hemostatic and Thrombotic Diseases Project 5 - Metabolic Causes of Thrombosis in Type 2 Diabetes
Status:
COMPLETED
Status Verified Date:
2019-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Hypoglycemia low blood glucose level occurs frequently in intensively treated patients with diabetes Although hypoglycemia was thought to occur almost exclusively in T1DM with the advent of improved metabolic control in T2DM the incidence of hypoglycemia is rising in these patients Therefore in this application we will test the novel hypothesis that prior hypoglycemia will result in cardiovascular complications during subsequent hypoglycemia
Detailed Description:
This study will test the hypothesis that 1 hypoglycemia causes a prothrombotic state and defective endothelial function and 2 episodes of repeated hypoglycemia will result in greater impairments of endothelial function and an increased prothrombotic tendency Preliminary data in healthy men demonstrates that hypoglycemia can dramatically increase PAI-1 levels and the PAI-1 to tPA ratio thereby creating a prothrombotic state Whether this also occurs in type 2 DM patients is unknown Furthermore the effects of hypoglycemia on endothelial function in T2DM are also unknown
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| RFAHL04016 | None | None | None |