Ignite Creation Date:
2024-05-06 @ 7:59 PM
Last Modification Date:
2024-10-26 @ 3:18 PM
Study NCT ID:
NCT06218524
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-01-23
First Post:
2024-01-11
Brief Title:
The Effectiveness of HP and TMZ Synergism on Adult Recurrence GBM
Sponsor:
Southern Medical University China
Organization:
Southern Medical University China
Study Overview
Official Title:
Clinical Study for Evaluating the Effectiveness of Haloperidol and Temozolomide Synergism on Adult Recurrence Glioblastoma
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study of investigators indicated that TMZ can up-regulate dopamine D2 receptor DRD2 expression and mediates Ferroptosis inhibition and chemoresistance of GBM The clinical data also proved that the DRD2 expression in recurrent GBM is significantly higher than that in primary GBM Moreover the DRD2 antagonist haloperidol can attenuate the above function of DRD2 and increase the sensitivity of GBM to the TMZ by inducing fatal autophagy and ferroptosis In xenograft mice the combined usage of haloperidol and Temozolomide TMZ can significantly inhibit tumor growth and increase overall survival The investigators findings have been published in Clinical cancer research Haloperidol known as a butylbenzene antipsychotic drug has been widely used in several kinds of mental illnesses such as depression schizophrenia and Bipolar disorder And the safe dosage of the haloperidol is clear so far So in this study the investigators will recruit the patients who suffered from recurrent GBM and evaluate the effectiveness of single TMZ chemotherapy or combined with haloperidol
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None