Ignite Creation Date:
2024-05-06 @ 7:59 PM
Last Modification Date:
2024-10-26 @ 3:18 PM
Study NCT ID:
NCT06213935
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-01-19
First Post:
2024-01-10
Brief Title:
Preoperative Oral Midodrine Versus Intraoperative Intravenous Norepinephrine in Preventing Post-spinal Anesthesia Hypotension in Cesarean Section A Prospective Double-blind Randomized Clinical Trial
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Preoperative Oral Midodrine Versus Intraoperative Intravenous Norepinephrine in Preventing Post-spinal Anesthesia Hypotension in Cesarean Section A Prospective Double-blind Randomized Clinical Trial
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Neuraxial blockade such as spinal anaesthesia can cause severe hypotension due to pharmacological sympathectomy resulting in potential deleterious consequences for the patient Prevention of this spinal anaesthesia induced hypotension is of utmost importance Techniques currently in use for preventing hypotension include intravenous fluid prehydration sympathomimetic drugs and physical methods such as positioning and leg compression
Midodrine is an orally active α-adrenergic agonist Used in clinical management of patients with orthostatic hypotension or hypotension secondary to other clinical conditions or drug therapies Midodrine is almost completely absorbed after oral administration and undergoes enzymatic hydrolysis to form its pharmacologically active metabolite de-glymidodrine causes venous and arterial vasoconstriction through stimulation of α1- receptors located in the vasculature However Midodrine may cause several side effects as chills numbness tingling paresthesia polyuria dysuria and headache
On the other hand Norepinephrine is a vasoconstrictor that predominantly stimulates α1 receptors to cause peripheral vasoconstriction and increase blood pressure It also has some β1 receptor agonist activity that results in a positive inotropic effect on the heart at higher doses Norepinephrine also may cause side effects as headache blurred vision chest pain nervousness bradycardia or tachycardia
Midodrine is an orally active α-adrenergic agonist Used in clinical management of patients with orthostatic hypotension or hypotension secondary to other clinical conditions or drug therapies Midodrine is almost completely absorbed after oral administration and undergoes enzymatic hydrolysis to form its pharmacologically active metabolite de-glymidodrine causes venous and arterial vasoconstriction through stimulation of α1- receptors located in the vasculature However Midodrine may cause several side effects as chills numbness tingling paresthesia polyuria dysuria and headache
On the other hand Norepinephrine is a vasoconstrictor that predominantly stimulates α1 receptors to cause peripheral vasoconstriction and increase blood pressure It also has some β1 receptor agonist activity that results in a positive inotropic effect on the heart at higher doses Norepinephrine also may cause side effects as headache blurred vision chest pain nervousness bradycardia or tachycardia
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None