Ignite Creation Date:
2024-05-06 @ 7:58 PM
Last Modification Date:
2024-10-26 @ 3:18 PM
Study NCT ID:
NCT06206928
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-01-16
First Post:
2023-12-27
Brief Title:
Evaluation of Mitochondrial Enzyme Activity in Cesarean Section Patients
Sponsor:
Sanliurfa Mehmet Akif Inan Education and Research Hospital
Organization:
Sanliurfa Mehmet Akif Inan Education and Research Hospital
Study Overview
Official Title:
Investigation of Trace Element Metabolism and Tricarboxylic Acid Cycle Enzyme Activities in Patients Who Underwent Cesarean Section With Spinal Anesthesia
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this observational study is to learn about in effects of trace element metabolism tricarboxylic acid cycle enzyme activities and thioldisulfide balance in patients who underwent cesarean section under spinal anesthesia The main questions it aims to answer are
What is the effect of trace element metabolism tricarboxylic acid cycle enzyme activities and thioldisulfide balance in patients undergoing cesarean section under regional anesthesia A 10 ml blood sample will be taken from the participants to analyze the biochemical parameters mentioned before and after the operation Pre- and post-operative values will be compared
What is the effect of trace element metabolism tricarboxylic acid cycle enzyme activities and thioldisulfide balance in patients undergoing cesarean section under regional anesthesia A 10 ml blood sample will be taken from the participants to analyze the biochemical parameters mentioned before and after the operation Pre- and post-operative values will be compared
Detailed Description:
Although the World Health Organization recommends the cesarean birth rate as 10-15 the cesarean birth rate in Turkey is 573 according to 2020 data ranking first in the world This rate is around 30 for primary cesarean delivery Although there are various methods of anesthesia for cesarean birth spinal block is a regional anesthesia method frequently used in elective cesarean births because it is easy to apply has a rapid onset of effect and provides a good sensory block With this anesthesia method local anesthetic solution is administered to the subarachnoid space to create sensory and motor block within the surgical area
Although trace elements Zinc Zn Iron Fe Copper Cu constitute a small part of the human body they play a very important role in maintaining normal metabolic function Deficiency or excess of these elements causes dysfunction of the relevant enzymes such as alcohol dehydrogenase alkaline phosphatase lactate dehydrogenase carboxypeptidase carbonic anhydrase superoxide dismutase SOD DNA and RNA polymerase and thus various clinical findings postpartum hemorrhage fetal growth restriction FGR fetal malformations premature birth preeclampsia
In recent years it has been revealed that thiol-disulfide homeostasis may be an important biomarker of oxidative stress Thiol is a compound containing sulfhydryl group -SH that plays an important role in preventing oxidative stress in cells Thiols are not only a redox buffer in the body but also an essential element of the antioxidant defense system Abnormal thiol-disulfide balance levels are associated with oxidative stress There is a balance between oxidative stress and antioxidant defense mechanisms The changes in this balance depending on many factors are frequently investigated in patients undergoing surgery
This study aimed to contribute to the literature by investigating the effects of trace element metabolism tricarboxylic acid cycle enzyme activities and thioldisulfide balance in patients who underwent cesarean section under spinal anesthesia
Although trace elements Zinc Zn Iron Fe Copper Cu constitute a small part of the human body they play a very important role in maintaining normal metabolic function Deficiency or excess of these elements causes dysfunction of the relevant enzymes such as alcohol dehydrogenase alkaline phosphatase lactate dehydrogenase carboxypeptidase carbonic anhydrase superoxide dismutase SOD DNA and RNA polymerase and thus various clinical findings postpartum hemorrhage fetal growth restriction FGR fetal malformations premature birth preeclampsia
In recent years it has been revealed that thiol-disulfide homeostasis may be an important biomarker of oxidative stress Thiol is a compound containing sulfhydryl group -SH that plays an important role in preventing oxidative stress in cells Thiols are not only a redox buffer in the body but also an essential element of the antioxidant defense system Abnormal thiol-disulfide balance levels are associated with oxidative stress There is a balance between oxidative stress and antioxidant defense mechanisms The changes in this balance depending on many factors are frequently investigated in patients undergoing surgery
This study aimed to contribute to the literature by investigating the effects of trace element metabolism tricarboxylic acid cycle enzyme activities and thioldisulfide balance in patients who underwent cesarean section under spinal anesthesia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None