Ignite Creation Date:
2024-05-06 @ 7:58 PM
Last Modification Date:
2024-10-26 @ 3:17 PM
Study NCT ID:
NCT06201975
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-01-11
First Post:
2024-01-02
Brief Title:
Efficacy of Thyme Honey as a Novel Adjunct to Non-surgical Periodontal Therapy
Sponsor:
British University In Egypt
Organization:
British University In Egypt
Study Overview
Official Title:
Efficacy of Locally Delivered Thyme Honey as a Novel Adjunct to Non-surgical Periodontal Therapy A Randomized Controlled Clinical Trial
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Periodontal diseases are disease processes involving the periodontium a term used to describe the supportive apparatus surrounding the tooth which includes the gingival tissue alveolar bone cementum and periodontal ligament Thyme honey as a conventional therapy might be a novel antioxidant to abate many of the diseases directly or indirectly associated with oxidative stress To the best of the researchers knowledge there are no published studies on the management of periodontitis in using locally delivered Thyme honey
Detailed Description:
In 2017 the American Academy of Periodontology in collaboration with the European Federation of Periodontology devised a new classification of periodontal and peri-implant diseases In this new classification periodontitis can be subdivided into three categories Necrotizing periodontal diseases Periodontitis Periodontitis as a manifestation of systemic diseases
Non-surgical treatment is valuable in mild to moderate periodontitis whereas surgical treatment is useful in progressive cases Confined drug delivery systems-mouth rinses irrigating solutions and sustained release devices are used for distribution of antimicrobial agents
It has been observed that artificial antimicrobial agents and antibiotics are identified to cause antimicrobial resistance It has also been observed that appearance of formerly rare infections is on the rise perhaps due to the incorrect or prevalent overuse of antimicrobials Natural phytochemicals have demonstrated to be worthy substitutes to synthetic agents
It is interesting fact to note that two of the most populated countries in the world China and India have used herbal medicine for the managing of oral infections comprising periodontal disease as well for more than a duration of 2000 years
It has been found that in adults with chronic periodontitis scaling and root planning along with use of an adjunctive antimicrobial mediator increases patient outcomes over a period of time compared to scaling alone Modern chemotherapeutic agents display significant efficacy in improving periodontal health but owing to undesirable side effects such as tooth discoloration taste alteration and price of these substances the usage of herbal products has increased lately and could be especially of high benefit to lower socioeconomic populations around the world
Herbal medicines and preparations comprise of plant constituents professed to have therapeutic benefits Herbal products are favored over conventional drugs owing to extensive natural activity advanced safety margin and inferior costs Additionally the modern drugs are known to cause several side effects Continuous intake of modern drugs has sometimes caused in antibiotic resistance thereby herbal medicines are being used gradually as dietary add-ons to combat or avert common ailments affecting human body and oral cavity
Honey as a natural product has clinched the attention of researchers as a complementary and alternative medicine Honey as a folk medicine is referred in the utmost ancient written archives
Demarcation of its uses in current professional medicine as a potential therapy is entirely underutilized However there is an affinity for some researchers to fire out a coherent proposition that usage of honey as a natural product supplement is well intentioned for reflection as a therapy or adjuvant antioxidant therapy in current medicine The composition of honey varies from floral source to origin
Thyme honey has been studied against various ailments in animal and human models Published research denotes it as a novel antioxidant agent It exhibits a broad spectrum therapeutic properties such as anti-inflammatory antibacterial antimutagenic expedite wound healings antidiabetic antiviral antifungal and antitumor effects
Additionally the anti-inflammatory properties of Greek thymus vulgaris extract was examined in recent research which reported its ability to reduce the LPS-induced elevation in cyclooxygenase COX-2 nuclear factor-kappa B NF-кB TNF-α and produced a more potent attenuating effect than dexamethasone for most of the studied inflammatory mediators
Moreover thymol was reported to possess an inhibitory effect on TNF-α IL-6 IFN-γ IL-1β and IL-17 C-reactive protein and myeloperoxidase Furthermore unfractionated essential oil from T vulgaris was found to reduce neutrophil infiltration during inflammatory responseThyme honey as a conventional therapy might be a novel antioxidant to abate many of the diseases directly or indirectly associated with oxidative stress To the best of the researchers knowledge there are no published studies on the management of periodontitis in using locally delivered Thyme honey
Non-surgical treatment is valuable in mild to moderate periodontitis whereas surgical treatment is useful in progressive cases Confined drug delivery systems-mouth rinses irrigating solutions and sustained release devices are used for distribution of antimicrobial agents
It has been observed that artificial antimicrobial agents and antibiotics are identified to cause antimicrobial resistance It has also been observed that appearance of formerly rare infections is on the rise perhaps due to the incorrect or prevalent overuse of antimicrobials Natural phytochemicals have demonstrated to be worthy substitutes to synthetic agents
It is interesting fact to note that two of the most populated countries in the world China and India have used herbal medicine for the managing of oral infections comprising periodontal disease as well for more than a duration of 2000 years
It has been found that in adults with chronic periodontitis scaling and root planning along with use of an adjunctive antimicrobial mediator increases patient outcomes over a period of time compared to scaling alone Modern chemotherapeutic agents display significant efficacy in improving periodontal health but owing to undesirable side effects such as tooth discoloration taste alteration and price of these substances the usage of herbal products has increased lately and could be especially of high benefit to lower socioeconomic populations around the world
Herbal medicines and preparations comprise of plant constituents professed to have therapeutic benefits Herbal products are favored over conventional drugs owing to extensive natural activity advanced safety margin and inferior costs Additionally the modern drugs are known to cause several side effects Continuous intake of modern drugs has sometimes caused in antibiotic resistance thereby herbal medicines are being used gradually as dietary add-ons to combat or avert common ailments affecting human body and oral cavity
Honey as a natural product has clinched the attention of researchers as a complementary and alternative medicine Honey as a folk medicine is referred in the utmost ancient written archives
Demarcation of its uses in current professional medicine as a potential therapy is entirely underutilized However there is an affinity for some researchers to fire out a coherent proposition that usage of honey as a natural product supplement is well intentioned for reflection as a therapy or adjuvant antioxidant therapy in current medicine The composition of honey varies from floral source to origin
Thyme honey has been studied against various ailments in animal and human models Published research denotes it as a novel antioxidant agent It exhibits a broad spectrum therapeutic properties such as anti-inflammatory antibacterial antimutagenic expedite wound healings antidiabetic antiviral antifungal and antitumor effects
Additionally the anti-inflammatory properties of Greek thymus vulgaris extract was examined in recent research which reported its ability to reduce the LPS-induced elevation in cyclooxygenase COX-2 nuclear factor-kappa B NF-кB TNF-α and produced a more potent attenuating effect than dexamethasone for most of the studied inflammatory mediators
Moreover thymol was reported to possess an inhibitory effect on TNF-α IL-6 IFN-γ IL-1β and IL-17 C-reactive protein and myeloperoxidase Furthermore unfractionated essential oil from T vulgaris was found to reduce neutrophil infiltration during inflammatory responseThyme honey as a conventional therapy might be a novel antioxidant to abate many of the diseases directly or indirectly associated with oxidative stress To the best of the researchers knowledge there are no published studies on the management of periodontitis in using locally delivered Thyme honey
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None