Ignite Creation Date:
2024-05-06 @ 7:58 PM
Last Modification Date:
2024-10-26 @ 3:18 PM
Study NCT ID:
NCT06206655
Status:
RECRUITING
Last Update Posted:
2024-01-22
First Post:
2024-01-04
Brief Title:
Diagnosis of Adrenal Insufficiency in Liver Cirrhosis Patients
Sponsor:
Seoul National University Hospital
Organization:
Seoul National University Hospital
Study Overview
Official Title:
Investigation of Incidence and Proper Diagnostic Method for Adrenal Insufficiency in Liver Cirrhosis Patients
Status:
RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
DALI
Brief Summary:
Patients with liver cirrhosis LC often exhibit fatigue poor oral intake and abdominal discomfort which are the symptoms that are also shown in subjects with adrenal insufficiency AI Controversy exists upon over-diagnosis of adrenal insufficiency in patients with LC because decreased albumin andor cortisol binding protein lower total cortisol levels while free cortisol increasesor is preserved The investigators assumed that measuring salivary cortisol or direct free cortisol using mass-spectrometry would provide a more accurate level of cortisol in LC patients 50 patients with LC will be recruited and undergo a rapid ACTH stimulation test and their blood saliva will be collected and analyzed The difference between serum free cortisol and total cortisol as well as between salivary cortisol and total cortisol will be investigated to find the optimal way to diagnose AI in LC patients
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None