Ignite Creation Date:
2024-05-06 @ 7:58 PM
Last Modification Date:
2024-10-26 @ 3:17 PM
Study NCT ID:
NCT06204198
Status:
RECRUITING
Last Update Posted:
2024-01-12
First Post:
2024-01-03
Brief Title:
Clinicopathological Features and Molecular Typing of Invasive Fibroma of Abdominal Wall
Sponsor:
Shandong Provincial Hospital
Organization:
Shandong Provincial Hospital
Study Overview
Official Title:
Analysis of Clinicopathological Features and Molecular Typing of Invasive Fibroma of Abdominal Wall and Construction of Recurrence Risk Model
Status:
RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Aggressive fibromatosis also known as desmoid fibromatosis or desmoid tumor is a fibrous tumor that occurs in the fascia aponeurosis or deep soft tissue and is formed by excessive proliferation of fibroblasts and myofibroblasts At present the disease is considered to be a borderline tumor Due to the unclear boundary of the tumor it often grows into the surrounding adjacent tissues which is difficult to remove completely and easy to relapse It has been reported that nuclear β-catenin expression and CTNNB1 gene mutation can be used for the differential diagnosis of aggressive fibromatosis from other spindle cell lesions At present there is a lack of multicenter retrospective clinical study of this disease and there is no literature report on the postoperative quality of life of this kind of patients This study intends to further explore the clinicopathological features prognosis and molecular typing of abdominal wall aggressive fibroma by retrospective analysis of the case data of multiple hospitals as well as sequencing analysis of the retained specimens and paraffin specimens from previous operations to study the high risk factors for recurrence of the disease and to further comprehensively analyze the impact of abdominal wall aggressive fibroma surgery on the quality of life of patients through follow-up
Detailed Description:
The data of all patients with abdominal wall aggressive fibroma were collected through the medical record system of the hospital and the molecular characteristics of the disease were analyzed by sequencing of the specimens retained by previous surgery or paraffin specimens The quality of life of patients was investigated by telephone or wechat follow-up to analyze the impact of postoperative disease on the quality of life of patients As a retrospective and observational study the data of this study will be statistically summarized according to the following general principles Categorical data will be summarized descriptively using statistics including frequency n and percentage with 95 confidence intervals for overall percentages when necessary and compared by chi-square or Fishers exact test Continuous data will be statistically described as mean standard deviation or median min Max and compared by Mann-Whitney U test or t-test The Kaplan-Meier method was used to estimate the survival function for time-to-event data and survival curves were drawn to estimate the median time and 95 confidence intervals The differences between groups were compared with the use of the Log-rank test Cox proportional hazards model was used for univariate and multivariate analysis to screen independent prognostic factors related to recurrence and the 95 confidence interval CI was recorded All statistical tests were performed with the use of a two-sided 005 level Statistical analysis will be calculated using SPSS 25 statistical analysis software
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None