Ignite Creation Date:
2024-05-06 @ 7:57 PM
Last Modification Date:
2024-10-26 @ 3:17 PM
Study NCT ID:
NCT06194955
Status:
RECRUITING
Last Update Posted:
2024-05-07
First Post:
2023-12-22
Brief Title:
The Effect of GIP GLP-1 and GLP-2 in Individuals With Genetically Altered Receptor Function
Sponsor:
University of Copenhagen
Organization:
University of Copenhagen
Study Overview
Official Title:
The Effect of Glucose-dependent Insulinotropic Polypeptide GIP Glucagon-like Peptide-1 GLP-1 and Glucagon-like Peptide-2 GLP-2 in Individuals With Genetically Altered Receptor Function
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
H-21044858
Brief Summary:
This project will characterize the physiological effect of the hormones GIP- GLP-1- and GLP-2 infusions in a group of individuals that are carriers of GIP- GLP-1- and GLP-2 receptor gene variants respectively
Detailed Description:
Participants with mutations in their GLP-1- and GIP receptor will attend five randomized experimental days A1 A2 B C and D On day A1 an oral glucose tolerance test OGTT will be performed and on day A2 an intravenous isoglycaemic glucose infusion IIGI will be performed On experimental day B and C the study participants will receive GLP-1 and GIP hormones respectively under stable glucose infusions and on experimental day D they will receive infusion of salt water placebo under stable glucose infusion
Participants with mutations in their GLP-2 receptor will attend three randomized experimental days E F and G A mixed meal test MMT will be performed on day E an infusion with GLP-2 during fasting blood glucose levels will be performed on day F and infusion with salt water placebo during fasting blood glucose levels will be performed on day G
Additionally a DXA scan and arginine test will be performed on all study participants
Participants with mutations in their GLP-2 receptor will attend three randomized experimental days E F and G A mixed meal test MMT will be performed on day E an infusion with GLP-2 during fasting blood glucose levels will be performed on day F and infusion with salt water placebo during fasting blood glucose levels will be performed on day G
Additionally a DXA scan and arginine test will be performed on all study participants
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None