Ignite Creation Date:
2024-05-06 @ 7:57 PM
Last Modification Date:
2024-10-26 @ 3:17 PM
Study NCT ID:
NCT06198608
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-01-10
First Post:
2023-12-26
Brief Title:
Misdiagnosis Between Interstitial Lung Disease and Cardiac Patients
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Interstitial Lung Disease Misdiagnosis in Cardiac Patients
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Aim of the study To determine the frequency misdiagnosis of cardiac congestion as interstitial lung disease based on initial High Resolution CT interpretation alone
To identify specific HRCT findings that are more commonly associated with misdiagnosis versus correct diagnosis of the underlying condition
To establish diagnostic criteria or HRCT patterns that distinguish cardiac congestion from interstitial lung disease
To identify specific HRCT findings that are more commonly associated with misdiagnosis versus correct diagnosis of the underlying condition
To establish diagnostic criteria or HRCT patterns that distinguish cardiac congestion from interstitial lung disease
Detailed Description:
Observational study of 150 patients found that cardiac congestion was misdiagnosed as interstitial lung disease in 24 of cases on initial HRCT imaging alone Echocardiography and clinical correlation were needed to make the correct diagnosis
Misdiagnosis can lead to inappropriate treatment with immunosuppressive drugs which could exacerbate right heart failure in patients who actually have cardiac congestion Correct diagnosis is important for prognosis and management
Subtle findings like upper lobe predominance of opacities septal lines and a mosaic attenuation pattern on HRCT favor interstitial lung disease while diffuse ground glass with central and perihilar distribution favors cardiac congestion
Associated findings on HRCT like enlarged cardiac silhouette pleural and pericardial effusions help suggest the diagnosis of cardiac congestion over idiopathic interstitial pneumonia
Integrating clinical data on risk factors for heart failure echocardiography findings and follow-up imaging response to diuretic therapy can help differentiate the two conditions when HRCT is non-specific
Misdiagnosis can lead to inappropriate treatment with immunosuppressive drugs which could exacerbate right heart failure in patients who actually have cardiac congestion Correct diagnosis is important for prognosis and management
Subtle findings like upper lobe predominance of opacities septal lines and a mosaic attenuation pattern on HRCT favor interstitial lung disease while diffuse ground glass with central and perihilar distribution favors cardiac congestion
Associated findings on HRCT like enlarged cardiac silhouette pleural and pericardial effusions help suggest the diagnosis of cardiac congestion over idiopathic interstitial pneumonia
Integrating clinical data on risk factors for heart failure echocardiography findings and follow-up imaging response to diuretic therapy can help differentiate the two conditions when HRCT is non-specific
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None