Ignite Creation Date:
2024-05-06 @ 7:57 PM
Last Modification Date:
2024-10-26 @ 3:17 PM
Study NCT ID:
NCT06191419
Status:
RECRUITING
Last Update Posted:
2024-04-08
First Post:
2023-12-20
Brief Title:
Human Perception of Odors and Odor Blockers
Sponsor:
Tim McClintock
Organization:
University of Kentucky
Study Overview
Official Title:
Human Perception of Odors and Odor Blockers
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this clinical trial is to determine whether blockers of perception of key odorants in cigarette smoke have any utility in smoking cessation The main question it aims to answer is
Can odor blockers be used to suppress perception of the intensity of cigarette smoke in ways that reduce the ability of the odor of cigarette smoke to increase the urge to smoke
Participants will be asked to smell up to 20 odor samples per session and report on odor pleasantness and desire to smoke
Can odor blockers be used to suppress perception of the intensity of cigarette smoke in ways that reduce the ability of the odor of cigarette smoke to increase the urge to smoke
Participants will be asked to smell up to 20 odor samples per session and report on odor pleasantness and desire to smoke
Detailed Description:
The experimental treatments include controls clean air irrelevant odor blocking odors cigarette smoke odor and cigarette smoke odor mixed with blocking odors or irrelevant odor To obtain cigarette smoke odor a 1 inch length of a 1R6F research cigarette is burned to completion in a sealed 5 gallon chamber fitted with septa Using a syringe fit with a needle and filter 60 mL aliquots of smoke odor are obtained These smoke odor aliquots along with blocking odors are injected into odor sample bags fit with a septum and a valve that can be attached to the CPAP nose mask worn by each participating smoker Participants open the valve inhale once through the nose close the valve and then remove the bag from the mask before reporting odor pleasantness and the desire to smoke A 2 - 3 min wait period is enforced between each odor presentation to prevent odor adaptation and to allow acute motivational effects to subside
In a testing session a participant sniffs 4 concentrations of a mixture of 2 blocking odors along with control odor samples Presentation order is randomized Each participant is assigned their own CPAP nose mask and masks are disinfected after use Participants also provide demographic age sex ethnic and racial background and smoking history information cigarettes per day preferred brand age at onset and time since last cigarette
In a testing session a participant sniffs 4 concentrations of a mixture of 2 blocking odors along with control odor samples Presentation order is randomized Each participant is assigned their own CPAP nose mask and masks are disinfected after use Participants also provide demographic age sex ethnic and racial background and smoking history information cigarettes per day preferred brand age at onset and time since last cigarette
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1K18DC020155 | NIH | None | httpsreporternihgovquickSearch1K18DC020155 |