Ignite Creation Date:
2024-05-06 @ 7:56 PM
Last Modification Date:
2024-10-26 @ 3:17 PM
Study NCT ID:
NCT06191471
Status:
COMPLETED
Last Update Posted:
2024-01-05
First Post:
2023-12-20
Brief Title:
Hepatitis A Virus Induced Acute Acalculous Cholecystitis Diagnosed Postoperatively Case Report
Sponsor:
University of Balamand
Organization:
University of Balamand
Study Overview
Official Title:
Hepatitis A Virus Induced Acute Acalculous Cholecystitis Diagnosed Postoperatively Case Report
Status:
COMPLETED
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
41-year-old previously healthy patient presented with right upper quadrant abdominal pain Pain started two days prior to presentation when an abdominal ultrasound in a peripheral hospital showed a 10 mm gallbladder stone with normal laboratory tests however her pain was resolved on analgesics Now the pain was persistent and associated with vomiting and laboratory tests showed elevated bilirubin Laparoscopic cholecystectomy with intraoperative cholangiography was done that showed inflamed gallbladder but with no stones and normal cholangiography Day one post-operation while the pain resolved labs showed elevated liver function tests and hepatitis workup showed acute HAV infection attributing her presentation to HAV induced AAC
Detailed Description:
Introduction acute acalculous cholecystitis AAC is defined as gallbladder inflammation without the presence of stones Contrary hepatitis A virus HAV causes acute hepatitis A and can present with different symptoms however HAV causing and presenting as AAC is rare
Case presentation 41-year-old previously healthy patient presented with right upper quadrant abdominal pain Pain started two days prior to presentation when an abdominal ultrasound in a peripheral hospital showed a 10 mm gallbladder stone with normal laboratory tests however her pain was resolved on analgesics Now the pain was persistent and associated with vomiting and laboratory tests showed elevated bilirubin Laparoscopic cholecystectomy with intraoperative cholangiography was done that showed inflamed gallbladder but with no stones and normal cholangiography Day one post-operation while the pain resolved labs showed elevated liver function tests and hepatitis workup showed acute HAV infection attributing her presentation to HAV induced AAC
Discussion AAC is usually caused by stasis of the gallbladder due to different causes however HAV as the cause of AAC has been reported While cholecystectomy is the mainstay treatment for AAC this might not be the case for HAV induced AAC For instance unless there is necrotic gallbladder or persistence of symptoms the AAC can be managed conservatively in this case Even though our diagnosis was cleared post-operatively had we know the diagnosis of HAV induced AAC before we would still opt for surgery due to the severity and persistence of pain
Conclusion More cases should be reported and more studies should be done to further define the presentation and management of HAV induced AAC
Case presentation 41-year-old previously healthy patient presented with right upper quadrant abdominal pain Pain started two days prior to presentation when an abdominal ultrasound in a peripheral hospital showed a 10 mm gallbladder stone with normal laboratory tests however her pain was resolved on analgesics Now the pain was persistent and associated with vomiting and laboratory tests showed elevated bilirubin Laparoscopic cholecystectomy with intraoperative cholangiography was done that showed inflamed gallbladder but with no stones and normal cholangiography Day one post-operation while the pain resolved labs showed elevated liver function tests and hepatitis workup showed acute HAV infection attributing her presentation to HAV induced AAC
Discussion AAC is usually caused by stasis of the gallbladder due to different causes however HAV as the cause of AAC has been reported While cholecystectomy is the mainstay treatment for AAC this might not be the case for HAV induced AAC For instance unless there is necrotic gallbladder or persistence of symptoms the AAC can be managed conservatively in this case Even though our diagnosis was cleared post-operatively had we know the diagnosis of HAV induced AAC before we would still opt for surgery due to the severity and persistence of pain
Conclusion More cases should be reported and more studies should be done to further define the presentation and management of HAV induced AAC
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None