Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005149
Status:
COMPLETED
Last Update Posted:
2016-01-21
First Post:
2000-05-25
Brief Title:
Genetic and Environmental Determinants of Hypertension
Sponsor:
University of Utah
Organization:
University of Utah
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2016-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine the pathophysiology of different types of essential hypertension by identifying the discrete effects of major genes and environmental variables as determinants of the subtypes of essential hypertension
Detailed Description:
BACKGROUND
Essential hypertension is believed to be a heterogeneous group of disorders the subtypes of which could be related to sodium sensitivity obesity diabetes calcium intake and metabolism the renin-angiotensin balance or membrane cation transport Essential hypertension aggregates in families The syndromes leading to hypertension may involve shared genes shared environmental factors or both
DESIGN NARRATIVE
In 1980 a series of biochemical and physiological tests were initiated in the 2548 persons in 98 extended pedigrees in Utah Most of the subjects were obtained from three major pedigree types stroke cluster pedigrees coronary heart disease cluster pedigrees and pedigrees of Utah Hypertension Detection and Follow-up Program high blood pressure probands Data were collected on personal history medical family history and genealogy anthropometrics standard and 32-lead electro- cardiograms multiple blood pressure measurements during sitting standing lying tilting isometric hand grip exercise bicycle exercise venipuncture and mental arithmetic Cation tests included sodium-lithium countertransport lithium-potassium co-transport intracellular sodium potassium magnesium sodium-potassium ATP-ase pump activity and binding sites and plasma levels of sodium potassium magnesium ionized calcium and digoxin-like pump inhibitor Information was also collected on stress exercise plasma renin activity and urinary kallikrein Statistical and pedigree analysis were conducted
The same tests were also performed on 600 new population-based hypertensive subjects on drug therapy and again four months after interruption of drug therapy Tests were conduced for specific subtypes of high blood pressure among the 600 subjects using individual variables and multivariate combinations of variables Three hundred nuclear families were screened to test for familiality of subtype indicators and to identify those high blood pressure subtype indicator variables needing detailed pedigree analysis
One thousand sequentially-sampled persons were studied for major genes DNA probe linkage and gene-environment interactions as determinants of specific types of hypertension
Essential hypertension is believed to be a heterogeneous group of disorders the subtypes of which could be related to sodium sensitivity obesity diabetes calcium intake and metabolism the renin-angiotensin balance or membrane cation transport Essential hypertension aggregates in families The syndromes leading to hypertension may involve shared genes shared environmental factors or both
DESIGN NARRATIVE
In 1980 a series of biochemical and physiological tests were initiated in the 2548 persons in 98 extended pedigrees in Utah Most of the subjects were obtained from three major pedigree types stroke cluster pedigrees coronary heart disease cluster pedigrees and pedigrees of Utah Hypertension Detection and Follow-up Program high blood pressure probands Data were collected on personal history medical family history and genealogy anthropometrics standard and 32-lead electro- cardiograms multiple blood pressure measurements during sitting standing lying tilting isometric hand grip exercise bicycle exercise venipuncture and mental arithmetic Cation tests included sodium-lithium countertransport lithium-potassium co-transport intracellular sodium potassium magnesium sodium-potassium ATP-ase pump activity and binding sites and plasma levels of sodium potassium magnesium ionized calcium and digoxin-like pump inhibitor Information was also collected on stress exercise plasma renin activity and urinary kallikrein Statistical and pedigree analysis were conducted
The same tests were also performed on 600 new population-based hypertensive subjects on drug therapy and again four months after interruption of drug therapy Tests were conduced for specific subtypes of high blood pressure among the 600 subjects using individual variables and multivariate combinations of variables Three hundred nuclear families were screened to test for familiality of subtype indicators and to identify those high blood pressure subtype indicator variables needing detailed pedigree analysis
One thousand sequentially-sampled persons were studied for major genes DNA probe linkage and gene-environment interactions as determinants of specific types of hypertension
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL024855 | NIH | None | httpsreporternihgovquickSearchR01HL024855 |