Ignite Creation Date:
2024-05-06 @ 7:56 PM
Last Modification Date:
2024-10-26 @ 3:16 PM
Study NCT ID:
NCT06183788
Status:
RECRUITING
Last Update Posted:
2024-05-06
First Post:
2023-05-19
Brief Title:
Antibody-mediated NMDA Receptor Encephalitis Symptoms Biomarkers and Mechanisms of the Prolonged Recovery Stage
Sponsor:
Fundacion Clinic per a la Recerca Biomédica
Organization:
Fundacion Clinic per a la Recerca Biomédica
Study Overview
Official Title:
Antibody-mediated NMDA Receptor Encephalitis Symptoms Biomarkers and Mechanisms of the Prolonged Recovery Stage
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
AMENDS
Brief Summary:
The encephalitis mediated by antibodies against the NMDA receptor NMDARe predominantly affects young adults and children resulting in severe neurologic and psychiatric deficits After overcoming the acute stage patients are left with long-lasting behavioral cognitive and psychiatric alterations with important socio-family-economical implications Here investigators postulate that a better knowledge of this stage will improve treatment decisions and outcome
In Aim 1 the post-acute stage will be clinically characterized tools to remotely follow cognitive behavioral and psychiatric deficits will be provided and the impact of cognitive rehabilitation will be assessed
In Aim 2 biomarkers autoimmune inflammatory neuronal injury will be identified as signatures of the acute and post-acute stages
In Aim 3 a mouse model of NMDARe will be used to determine the underlying mechanisms and treatment of the postacute stage
In Aim 1 the post-acute stage will be clinically characterized tools to remotely follow cognitive behavioral and psychiatric deficits will be provided and the impact of cognitive rehabilitation will be assessed
In Aim 2 biomarkers autoimmune inflammatory neuronal injury will be identified as signatures of the acute and post-acute stages
In Aim 3 a mouse model of NMDARe will be used to determine the underlying mechanisms and treatment of the postacute stage
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None