Ignite Creation Date:
2024-05-06 @ 7:55 PM
Last Modification Date:
2024-10-26 @ 3:16 PM
Study NCT ID:
NCT06183424
Status:
RECRUITING
Last Update Posted:
2023-12-27
First Post:
2023-12-25
Brief Title:
TDCS Stimulation After Covid-19 Infection
Sponsor:
Istanbul Medipol University Hospital
Organization:
Istanbul Medipol University Hospital
Study Overview
Official Title:
Effects of aTDCS Stimulation of the Dorsolateral Prefrontal Cortex on Cognitive Functions and the Parietal Memory Network Default Mode Network in Patients Presenting Cognitive Symptoms After Covid-19 Infection A Controlled Randomized Clinical Trial
Status:
RECRUITING
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In this study the effects of bilateral stimulation of the dorsolateral prefrontal cortex DLPFC with active tDCS transcranial direct stimulationtranscranial direct stimulation on neurocognitive memory and executive functions in patients with Covid-19 infection and subjective cognitive complaints as well as resting-state fMRI In the case of dfMRI it is aimed to examine the default mode network DMN and parietal memory network PMN inter- and intra-network connectivity alterations and the hippocampal region connectivity alterations and contribute to the relevant literature
Detailed Description:
The DMN is active when not engaged in a goal-oriented activity and at rest Resting DNM is especially active when the mind is busy with introspective situations Barkhof et al 2014 Mak et al 2017 Although the posterior parts of the DMN consisting of the posterior cingulateprecuneus and bilateral parietal cortex regions are associated with memory functions memory functions are not unique to DMN and the parietal regions are not functionally homogeneous Sestieri et al 2011 At this point a new network called the parietal memory network PMN was defined in a study by Gilmore Gilmore et al 2015 This network is a system that diverges from the posterior parts of the DMN and consists of the middle cingulate cortex precuneus and inferior parietal lobuleangular gyrus structures and has overlapping regions with the DMN This network appears to differ from the DMN in different types of recall memory functions Accordingly when recalling autobiographical information DMN PMN seems to be active in encoding and recall tasks related to recognition memory McDermott et al 2009 Chen et al 2017 Nelson et al 2013 Hu et al 2016 Manenti et al 2010 Kragel et al 2016 A double dissociation appears to occur between these two network systems in memory processes and furthermore the spacial proximity of PMN to the DMN suggests that some of the cognitive dysfunctions attributed to the DMN of these two systems are due to PMN The fact that PMN is associated with memory encoding and recall functions even in different types of tasks de-activity in perceiving new stimulus but being active in perceiving familiar stimulus differentiates it from other network systems Stimulation of the parietal region with repetitive transcranial magnetic stimulation rTMS resulted in improved visual recognition memory performance Velioğlu et al 2021
The dorsolateral prefrontal cortex DLPFC is the central region associated with executive functions and damage to this region is associated with difficulty in regulating behavioral responses memory-retrieval and inability to demonstrate appropriate motor behavior Damages in this region are associated with cognitive loss in related areas Liu et al 2021 Brak et al 2022 tDCS on the other hand stands out as a promising method for patients with Covid-19 infection and subjective cognitive complaints and appears to act by modulating functional connectivity Baptista 2020 Linnhoff 2023 Yulug B Increased connectivity between the hippocampus and other DMN nodes such as the dorsal attention network control attention-attractiveness network and sensori-motor networks was detected in fMRI with atDCS stimulation Manenti et al 2020 Meinzer et al 2015 In this context improvement in neurocognitive tests and changes in functional imaging can be detected with stimulation of the relevant regions of the cortex with tDCS in patients who have had Covid-19 infection and have subjective cognitive complaints In patients with Covid-19 infection stimulation of the relevant regions with tDCS resulted in improvement in cognitive functions such as working memory and cognitive control Baptista 2020 Linnhoff 2023 Yulug B2023 At this point DLPFC stimulation may also result in improved cognitive functions regarding encoding and recall
From this point of view in this study -based on the studies referenced in the text- bilateral stimulation of the DLPFC region with anodal tDCS atDCS increased performance in neurocognitive abilities especially memory and executive functions in patients who had Covid-19 infection and had subjective cognitive complaints The methodical mesh is shaped in the context of this template hypothesizing that it will result in In addition in the fMRI studies mentioned above it is aimed to point out that tDCS stimulation increases the coherence between DMN networks and to examine the effect of tDCS stimulation on DMN network connectivity and connectivity with the hippocampal region with reference to the role of PMN in patients with Covid-19 infection and subjective cognitive complaints From this point of view the aim of this study is dorsolateral prefrontal cortex DLPFC active tDCS transcranial direct stimulationtranscribed in patients with covid-19 infection and subjective cognitive complaints
The dorsolateral prefrontal cortex DLPFC is the central region associated with executive functions and damage to this region is associated with difficulty in regulating behavioral responses memory-retrieval and inability to demonstrate appropriate motor behavior Damages in this region are associated with cognitive loss in related areas Liu et al 2021 Brak et al 2022 tDCS on the other hand stands out as a promising method for patients with Covid-19 infection and subjective cognitive complaints and appears to act by modulating functional connectivity Baptista 2020 Linnhoff 2023 Yulug B Increased connectivity between the hippocampus and other DMN nodes such as the dorsal attention network control attention-attractiveness network and sensori-motor networks was detected in fMRI with atDCS stimulation Manenti et al 2020 Meinzer et al 2015 In this context improvement in neurocognitive tests and changes in functional imaging can be detected with stimulation of the relevant regions of the cortex with tDCS in patients who have had Covid-19 infection and have subjective cognitive complaints In patients with Covid-19 infection stimulation of the relevant regions with tDCS resulted in improvement in cognitive functions such as working memory and cognitive control Baptista 2020 Linnhoff 2023 Yulug B2023 At this point DLPFC stimulation may also result in improved cognitive functions regarding encoding and recall
From this point of view in this study -based on the studies referenced in the text- bilateral stimulation of the DLPFC region with anodal tDCS atDCS increased performance in neurocognitive abilities especially memory and executive functions in patients who had Covid-19 infection and had subjective cognitive complaints The methodical mesh is shaped in the context of this template hypothesizing that it will result in In addition in the fMRI studies mentioned above it is aimed to point out that tDCS stimulation increases the coherence between DMN networks and to examine the effect of tDCS stimulation on DMN network connectivity and connectivity with the hippocampal region with reference to the role of PMN in patients with Covid-19 infection and subjective cognitive complaints From this point of view the aim of this study is dorsolateral prefrontal cortex DLPFC active tDCS transcranial direct stimulationtranscribed in patients with covid-19 infection and subjective cognitive complaints
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None