Ignite Creation Date:
2024-05-06 @ 7:55 PM
Last Modification Date:
2024-10-26 @ 3:17 PM
Study NCT ID:
NCT06188195
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-01-26
First Post:
2023-11-27
Brief Title:
Establishment and Evaluation of Prenatal Prevention and Treatment Strategy for NARDS
Sponsor:
The Second Affiliated Hospital of Chongqing Medical University
Organization:
The Second Affiliated Hospital of Chongqing Medical University
Study Overview
Official Title:
Establishment and Evaluation of Prenatal Prevention and Treatment Strategy for Neonatal Acute Respiratory Distress Syndrome
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1 A predictive model for NARDS was established based on perinatal risk factors Multivariate Logistic regression analysis was used to screen the independent prenatal risk factors for NARDS A Logistic regression model was constructed using the above independent risk factors and quantified in a nomogram to construct a visualization model for prenatal prediction of NARDS
2 The role of ACS in the prevention and treatment of ARDS in near-termfull-term infants
For neonates with a probability greater than 80 in the prediction model of ARDS at least one ACS was given before the termination of pregnancy The GC level of cord blood taken at birth and the mRNA levels of α-ENaC Na-K-atpase and SGK1 in nasal epithelium were measured within 2 hours and 1 day after birth in the ACS intervention group and the control group The occurrence and severity of pulmonary edema the occurrence and severity of ARDS and the mortality rate of NARDS were evaluated by lung ultrasound The indexes of the two groups were compared horizontally and longitudinally
2 The role of ACS in the prevention and treatment of ARDS in near-termfull-term infants
For neonates with a probability greater than 80 in the prediction model of ARDS at least one ACS was given before the termination of pregnancy The GC level of cord blood taken at birth and the mRNA levels of α-ENaC Na-K-atpase and SGK1 in nasal epithelium were measured within 2 hours and 1 day after birth in the ACS intervention group and the control group The occurrence and severity of pulmonary edema the occurrence and severity of ARDS and the mortality rate of NARDS were evaluated by lung ultrasound The indexes of the two groups were compared horizontally and longitudinally
Detailed Description:
Based on the proposed scientific hypothesis the project team intends to achieve the following research objectives through scientific experiments
To explore the role of ACS in promoting fetal lung maturation from the perspective of lung fluid clearance through the traditional concept that ACS promotes fetal lung maturation mainly by inducing PS so as to further expand the object and scope of ACS application
The prenatal prediction model of ARDS was established by using perinatal risk factors and the predictive value was visualized
To explore the clinical value and mechanism of ACS in pregnant women at high risk of NARDS and to open up new ideas for the prevention and treatment of NARDS from the perspective of promoting lung fluid clearance The early prevention and treatment strategy of NARDS was established by combining the prenatal prediction model ACS and its effect was evaluated
To explore the role of ACS in promoting fetal lung maturation from the perspective of lung fluid clearance through the traditional concept that ACS promotes fetal lung maturation mainly by inducing PS so as to further expand the object and scope of ACS application
The prenatal prediction model of ARDS was established by using perinatal risk factors and the predictive value was visualized
To explore the clinical value and mechanism of ACS in pregnant women at high risk of NARDS and to open up new ideas for the prevention and treatment of NARDS from the perspective of promoting lung fluid clearance The early prevention and treatment strategy of NARDS was established by combining the prenatal prediction model ACS and its effect was evaluated
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None