Ignite Creation Date:
2024-05-06 @ 7:55 PM
Last Modification Date:
2024-10-26 @ 3:16 PM
Study NCT ID:
NCT06183554
Status:
RECRUITING
Last Update Posted:
2024-01-03
First Post:
2023-12-14
Brief Title:
CXCR4 Targeted PET Imaging in the Diagnosis and Identification of Primary Aldosteronism
Sponsor:
Xiao Chen
Organization:
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Study Overview
Official Title:
CXCR4 Targeted PET Imaging in the Diagnosis and Identification of Primary Aldosteronism
Status:
RECRUITING
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aimed to prospectively evaluate the utility of C-X-C chemokine receptor type 4 CXCR4 positron emission tomography PET imaging in patients with clinical suspected primary aldosteronism PA with postoperative pathological or follow-up results as reference standards
Detailed Description:
1 Record the course of disease the laboratory examination eg potassium aldosterone aldosterone-to-renin ratio intravenous salt-loading test or captopril test and the results of adrenal vein sampling in patients with clinically suspected PA
2 PET image analysis Record and evaluate the following indicators the maximum standardized uptake value SUVmax of lesions the mean standardized uptake value SUVmean of normal liver the SUVmean of adjacent normal adrenal tissue the ratio of the lesional SUVmax to the normal liver SUVmean LLR and the ratio of the lesional SUVmax to the adjacent adrenal tissue SUVmean LAR
3 Pathological analysis Hematoxylin and eosin staining and immunohistochemical analyses will be performed Immunohistochemical analysis will be used to investigate the expression of aldosterone synthase CYP11B2 and CXCR4
2 PET image analysis Record and evaluate the following indicators the maximum standardized uptake value SUVmax of lesions the mean standardized uptake value SUVmean of normal liver the SUVmean of adjacent normal adrenal tissue the ratio of the lesional SUVmax to the normal liver SUVmean LLR and the ratio of the lesional SUVmax to the adjacent adrenal tissue SUVmean LAR
3 Pathological analysis Hematoxylin and eosin staining and immunohistochemical analyses will be performed Immunohistochemical analysis will be used to investigate the expression of aldosterone synthase CYP11B2 and CXCR4
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None