Ignite Creation Date:
2024-05-06 @ 7:55 PM
Last Modification Date:
2024-10-26 @ 3:16 PM
Study NCT ID:
NCT06181981
Status:
RECRUITING
Last Update Posted:
2023-12-26
First Post:
2023-12-13
Brief Title:
Leucoaraiosis and Multimodal MRI With Fingerprinting Technique
Sponsor:
Lille Catholic University
Organization:
Lille Catholic University
Study Overview
Official Title:
Longitudinal Evaluation of Leucoaraiosis Using Multimodal MRI With Fingerprinting Technique
Status:
RECRUITING
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
LEUKOPRINT
Brief Summary:
Leukoaraiosis LA corresponds to an alteration of the encephalic white matter linked to chronic hypoxia Its pathophysiology which has been partially elucidated is underpinned by chronic changes in the walls of small-caliber perforating arteries leading to chronic hypoperfusion of the white matter associated with dysfunction of the blood-brain barrier In affected areas this process leads to myelin rarefaction axonal loss perivascular alterations and the appearance of cavitation zones Its existence is mainly linked to the presence of vascular risk factors most notably arterial hypertension
MR fingerprinting is an innovative Magnetic resonance Imaging MRI technique allowing to obtain a multiparametric MRI sequence in a non-invasively way and in a single acquisition generating not only multiple contrasts but also absolute longitudinal relaxation time T1 and transverse relaxation time T2 mappings T1 and T2 mapping However the prognostic role of these T2 values in terms of ischemic hemorrhagic and cognitive risk has never been studied The objective of this study is to study and compare changes in T1 and T2 values of White Matter Hyperintensities WMH and Normal Appearing White Matter NAWM in subjects with LA
MR fingerprinting is an innovative Magnetic resonance Imaging MRI technique allowing to obtain a multiparametric MRI sequence in a non-invasively way and in a single acquisition generating not only multiple contrasts but also absolute longitudinal relaxation time T1 and transverse relaxation time T2 mappings T1 and T2 mapping However the prognostic role of these T2 values in terms of ischemic hemorrhagic and cognitive risk has never been studied The objective of this study is to study and compare changes in T1 and T2 values of White Matter Hyperintensities WMH and Normal Appearing White Matter NAWM in subjects with LA
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None