Ignite Creation Date:
2024-05-06 @ 7:54 PM
Last Modification Date:
2024-10-26 @ 3:16 PM
Study NCT ID:
NCT06171451
Status:
COMPLETED
Last Update Posted:
2023-12-14
First Post:
2023-12-04
Brief Title:
Prognostic Values of PET Examination With 11 C-Fe_CIT With Voxel-based Analysis Method in Patients With Sporadic Parkonsons Disease and Parkinsonisms ProtPD-diagn
Sponsor:
IRCCS San Raffaele
Organization:
IRCCS San Raffaele
Study Overview
Official Title:
Prognostic Values of PET Examination With 11 C-Fe_CIT With Voxel-based Analysis Method in Patients With Sporadic Parkonsons Disease and Parkinsonisms ProtPD-diagn
Status:
COMPLETED
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The role of PET for the in vivo study of the presynaptic dopaminergic system with 11C-Fe-CIT is universally recognized and its use has also become routine in numerous nuclear medicine centers in Europe The indication for the examination is provided exclusively by the clinic in the presence of extrapyramidal signs in the suspicion of Parkinsons disease PD or for the differential diagnosis of parkinsonisms The existence of factors that influence the prognosis of patients with PD or parkinsonism associated with other degenerative diseases is known
Given these premises the possibility of identifying the disease in the early stages appears fundamental
For this purpose the following should be considered
1 an automatic analysis method based on the measurement of radiotracer uptake at the level of individual voxels following Statistical Parametric Mapping procedures
2 the analysis based on regions of interest ROIs positioned ad hoc by the operator which will give the value of the ROI to reference region ratio In particular ROIs on the basal ganglia caudate putamen towards cerebellum
Both of these methods offer a quantitative measurement of the damage at the level of the structures involved that is absolutely better than the visual investigation of the distribution of radioactivity in the central nervous system
In this study the investigators want to compare results provided by methods 1 and 2 in the populations under examination to evaluate the data relating to the specificity and sensitivity of the test
Given these premises the possibility of identifying the disease in the early stages appears fundamental
For this purpose the following should be considered
1 an automatic analysis method based on the measurement of radiotracer uptake at the level of individual voxels following Statistical Parametric Mapping procedures
2 the analysis based on regions of interest ROIs positioned ad hoc by the operator which will give the value of the ROI to reference region ratio In particular ROIs on the basal ganglia caudate putamen towards cerebellum
Both of these methods offer a quantitative measurement of the damage at the level of the structures involved that is absolutely better than the visual investigation of the distribution of radioactivity in the central nervous system
In this study the investigators want to compare results provided by methods 1 and 2 in the populations under examination to evaluate the data relating to the specificity and sensitivity of the test
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None