Ignite Creation Date:
2024-05-06 @ 7:53 PM
Last Modification Date:
2024-10-26 @ 3:16 PM
Study NCT ID:
NCT06177379
Status:
COMPLETED
Last Update Posted:
2023-12-20
First Post:
2023-12-11
Brief Title:
Magnetic Resonance Neurography Analysis of Healthy Human Thoracic Dorsal Root Ganglion
Sponsor:
Huazhong University of Science and Technology
Organization:
Huazhong University of Science and Technology
Study Overview
Official Title:
Magnetic Resonance Neurography Analysis of Healthy Human Thoracic Dorsal Root Ganglion
Status:
COMPLETED
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Here this study aimed to conduct magnetic resonance neurography MRN of the thoracic DRGs in a cohort of healthy individuals The acquired images will be thoroughly analyzed utilizing 3D-slicer software We expect to furnish crucial baseline anatomical data of thoracic DRGs in healthy subjects provide an anatomical basis for clinical investigation and therapeutic interventions
Detailed Description:
Chronic neuropathic pain remains a worlds public health challenges affecting hundreds of millions of people worldwide It is estimated that 112 of general-practice patients suffer from neuropathic pain and many continue to suffer from intractable pain andor undesirable side effects Neuropathic pain refers to the entire somatosensory system encompassing both central and peripheral neuropathic pain In recent years although significant advancements have been achieved in the mechanism and management of neuropathic pain and numerous pharmaceutical agents and therapeutic approaches have been utilized for its treatment the outcomes still to be less than optimal Moreover the adverse side effects associated with certain first- and second-line medications such as antidepressants and anticonvulsants as well as the potential for opioid addiction significantly impact patients adherence to treatment Hence there remains a need for continued investigation into effective strategies for the management of neuropathic pain
Therapies focused on the dorsal root ganglion DRG have emerged as a significant intervention in the clinical practice of pain physicians for the management of chronic pain given its integral and important role in the signals transmission from the peripheral nervous system to the central nervous system Accurate positioning holds paramount importance during the treatment process necessitating clinicians to possess a comprehensive understanding of the morphology distribution and interconnections of the dorsal root ganglia across various segments Currently there exists a limited number of in vivo investigations concerning the dorsal root ganglion DRG with a predominant emphasis on the lumbar segment which have mostly used invasive neuroradiography The investigation on thoracic DRG remains largely unexplored However herpes zoster the most prevalent form of neuropathic pain manifests most frequently in the thoracic segment Furthermore the studies of herpes zoster reveal that DRG plays a significant role in the progression of the disease and the transmission of pain signals Hence a comprehensive comprehension of the anatomy and variability of thoracic DRGs assumes significance not only in accurately comprehending the pathological anatomy of neuropathic pain in the thoracic region but also in providing guidance for interventional and individualized treatment targeting the DRGs
Therapies focused on the dorsal root ganglion DRG have emerged as a significant intervention in the clinical practice of pain physicians for the management of chronic pain given its integral and important role in the signals transmission from the peripheral nervous system to the central nervous system Accurate positioning holds paramount importance during the treatment process necessitating clinicians to possess a comprehensive understanding of the morphology distribution and interconnections of the dorsal root ganglia across various segments Currently there exists a limited number of in vivo investigations concerning the dorsal root ganglion DRG with a predominant emphasis on the lumbar segment which have mostly used invasive neuroradiography The investigation on thoracic DRG remains largely unexplored However herpes zoster the most prevalent form of neuropathic pain manifests most frequently in the thoracic segment Furthermore the studies of herpes zoster reveal that DRG plays a significant role in the progression of the disease and the transmission of pain signals Hence a comprehensive comprehension of the anatomy and variability of thoracic DRGs assumes significance not only in accurately comprehending the pathological anatomy of neuropathic pain in the thoracic region but also in providing guidance for interventional and individualized treatment targeting the DRGs
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None