Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001624
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Effect of Insulin on Endothelin-Dependent Vascular Tone in the Forearm Circulation
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Effect of Insulin on Endothelin-Dependent Vascular Tone in the Forearm Circulation
Status:
COMPLETED
Status Verified Date:
1999-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Previous studies have shown that insulin may stimulate the release of endothelin ET from endothelial cells This mechanism may contribute to the adverse vascular effects determined by chronic hyperinsulinemia The aim of this study will be to evaluate the effect of local hyperinsulinemia on ET activity in the forearm circulation To this purpose we will assess the forearm blood flow response to ET receptor antagonism in control conditions and during intraarterial infusion of insulin We will also measure changes in plasma ET-1 levels in response to the different pharmacological stimuli
Detailed Description:
Previous studies have shown that insulin may stimulate the release of endothelin ET from endothelial cells This mechanism may contribute to the adverse vascular effects determined by chronic hyperinsulinemia The aim of this study will be to evaluate the effect of local hyperinsulinemia on ET activity in the forearm circulation To this purpose we will assess the forearm blood flow response to ET receptor antagonism in control conditions and during intraarterial infusion of insulin We will also measure changes in plasma ET-1 levels in response to the different pharmacological stimuli
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 97-H-0100 | None | None | None |