Ignite Creation Date:
2024-05-06 @ 7:50 PM
Last Modification Date:
2024-10-26 @ 3:15 PM
Study NCT ID:
NCT06152211
Status:
RECRUITING
Last Update Posted:
2023-12-06
First Post:
2023-11-21
Brief Title:
Music-Based Interventions Aging Alzheimers Disease
Sponsor:
University of Southern California
Organization:
University of Southern California
Study Overview
Official Title:
Using Music-Based Interventions to Improve the Quality of Life and Wellbeing of Older Adults With or at Risk of Alzheimers Disease
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Using a randomized controlled trial design the investigators will examine the effects of music engagement through choir training on the hearing communication and psychosocial well-being of older adults particularly those at heightened risk of developing dementia
Detailed Description:
Major demographic transitions are underway in the developed world and adults aged 65 and over are the fastest growing segment of the United States population Aging is associated with the deterioration of sensory and perceptual processes as well as a decline in cognitive functioning including attention and working memory Advancing age is also associated with an increased risk of developing dementia including Alzheimers disease AD a progressive neurodegenerative condition The ε4 allele of APOE is one of three common alleles generated by cysteinearginine substitutions Although multiple genetic and environmental risk factors are involved in AD the possession of the ɛ4 allele is recognized as the most common identifiable genetic risk factor for late-onset AD The proportion of patients with AD that is attributable to the APOE ε4 is estimated to be 20 in people aged 55 years 5 Although the APOE 4 allele increases the risk of developing AD by three to fifteen times recent studies have shown that the risk can be modified by non-genetic factors including high education and leisure activities
Another significant and related problem of aging is a decline in hearing abilities Age-related hearing loss is a common problem for older adults leading to communication difficulties isolation and cognitive decline The difficulty understanding speech in noisy environments is one consequence of hearing loss that is particularly difficult to restore with hearing aids Speech-in-noise SIN perception appears to be supported by both the efficiency of bottom-up sound encoding and the influence of higher-level top-down processes such as auditory working memory and selective attention Decline in hearing and reduction in communication are associated with an increased rate of cognitive decline and the development of dementia in older adults Decline in SIN perception can also make it difficult for aging individuals to engage socially and maintain relationships and has been linked to loneliness and depression Indeed poor SIN perception may contribute to cognitive decline and increased risk of dementia both through taxing cognitive load and decreasing social engagement As a result there is a critical need for effective and accessible interventions that target hearing particularly interventions that are motivating and engaging and can be applied to the expanding population of older adults especially those at higher risk of AD The investigators will conduct an individually randomized group treatment trial to investigate the effects of choir training and its underlying neurobiological mechanisms on SIN perception and psychosocial well-being in adults ages 65 and older half carriers of APOE ε4 and the other half of non-carriers The investigators will randomly assign approximately 66 older adults to a 16-week 1 community choir program or 2 a group music listening program
Another significant and related problem of aging is a decline in hearing abilities Age-related hearing loss is a common problem for older adults leading to communication difficulties isolation and cognitive decline The difficulty understanding speech in noisy environments is one consequence of hearing loss that is particularly difficult to restore with hearing aids Speech-in-noise SIN perception appears to be supported by both the efficiency of bottom-up sound encoding and the influence of higher-level top-down processes such as auditory working memory and selective attention Decline in hearing and reduction in communication are associated with an increased rate of cognitive decline and the development of dementia in older adults Decline in SIN perception can also make it difficult for aging individuals to engage socially and maintain relationships and has been linked to loneliness and depression Indeed poor SIN perception may contribute to cognitive decline and increased risk of dementia both through taxing cognitive load and decreasing social engagement As a result there is a critical need for effective and accessible interventions that target hearing particularly interventions that are motivating and engaging and can be applied to the expanding population of older adults especially those at higher risk of AD The investigators will conduct an individually randomized group treatment trial to investigate the effects of choir training and its underlying neurobiological mechanisms on SIN perception and psychosocial well-being in adults ages 65 and older half carriers of APOE ε4 and the other half of non-carriers The investigators will randomly assign approximately 66 older adults to a 16-week 1 community choir program or 2 a group music listening program
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None