Ignite Creation Date:
2024-05-06 @ 7:50 PM
Last Modification Date:
2024-10-26 @ 3:15 PM
Study NCT ID:
NCT06156150
Status:
RECRUITING
Last Update Posted:
2023-12-05
First Post:
2023-11-26
Brief Title:
The Role of B7-H4 in Tumor Vaccine
Sponsor:
Huashan Hospital
Organization:
Huashan Hospital
Study Overview
Official Title:
The Role and Mechanism of B7-H4ATF3 Axis From Glioma Associated Macrophages in Treatment Resistance of Cancer Vaccine
Status:
RECRUITING
Status Verified Date:
2023-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Glioma patients have poor prognosis because of limited choices of treatment Therapeutic cancer vaccines have been proved to improve survival in glioma but resistance is a new challenge for vaccine treatment and the mechanism is unclear The applicant found in previous papers that glioma cells induced B7-H4 overexpression in macrophages and the expression level of B7-H4 is highly correlated with vaccine resistance Preliminary experiments indicated that B7-H4 protein in macrophages inhibited the expression of ATF3 STAT1 and CXCL910 which also resulted in decreased T cell infiltration in glioma model of mouse and was a negative factor of vaccine benefits Therefore the applicant hypothesize that B7-H4 inhibits STAT1 transcription by reducing expression of ATF3 resulting in decreased phosphorylated-STAT1 in nucleus which inhibiting expression and secretion of chemokines 910 Thereby reduced infiltration of T cells in microenvironment will be followed which ultimately promotes resistance of vaccine treatment in glioma The follow-up plan of this project will be conducted based on the cells organoid platform and animal experiments to confirm the role and mechanism of macrophage-derived B7-H4 in secretion of chemokines for T cells and treatment resistance of vaccines Moreover the DC vaccine produced by team of the applicant will be used to assess the probability of reversing vaccine resistance when intervening B7-H4 axis Finally a model for evaluating clinical benefits from vaccine will be established based on data from clinical trials combining with expression of B7-H4 and clinicopathologic features This study will provide new evidences for the treatment of cancer vaccines in gliomas
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 8230162487 | OTHER_GRANT | The National Natural Science Foundation of China | None |