Ignite Creation Date:
2024-05-06 @ 7:49 PM
Last Modification Date:
2024-10-26 @ 3:14 PM
Study NCT ID:
NCT06143150
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-11-22
First Post:
2023-11-07
Brief Title:
Prediction of Outcome of Non Invasive Ventilation COPD Patients by Assessment of Diaphragmatic Performance
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Can Transthoracic Ultrasound Assessment of the Diaphragmatic Performance Predict the Outcome of Non Invasive Ventilation in Critically Ill COPD Patients With Acute Exacerbation
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Transthoracic ultrasonographic assessment of the diaphragmatic performance as a predictor for the outcome of NIV in critically ill COPD patients with acute exacerbation
Detailed Description:
Chronic obstructive pulmonary disease COPD is considered a common disease worldwide and it poses a major health and economic problem
COPD was the fifth leading cause for death in 2022 and will rank third by 2030 So its considered a devastating disease for patients and their loved ones
Patients presented with acute exacerbations of COPD may need respiratory intensive care unit RICU admission Non invasive ventilation NIV is considered a cornerstone management option in patients with acute exacerbation of COPD AECOPD Therefore early prediction of NIV failure may help in decision making regarding escalation to invasive mechanical ventilation To date the diaphragm is the main respiratory muscle and derangement of its function is an important factor in the pathophysiology of COPD COPD patients have increased airway resistance and airflow limitation which in turn increases the mechanical load of breathing exerted on the diaphragm Diaphragmatic weakness in COPD patients results from decreased muscle strength and mobility Although diaphragmatic performance is a key determinant of dyspnea in COPD patients it is rarely assessed in clinical practice In practice only vital sign such as respiratory rate and arterial blood gases parameters ABG such as PH PaO2 PaCO2 SPO2 and fiO2paO2 are considered predictors of NIV outcome
Assessment of diaphragmatic function transthoracic ultrasound TUS is a reliable safe and bed side method for prediction of NIV outcome Several tools commonly applied to determine diaphragmatic function such as fluoroscopy Computed tomography CT transdiaphragmatic pressure measurement phrenic nerve stimulation and electromyography cant be routinely used in intensive care units due to technical challenges and limitations
COPD was the fifth leading cause for death in 2022 and will rank third by 2030 So its considered a devastating disease for patients and their loved ones
Patients presented with acute exacerbations of COPD may need respiratory intensive care unit RICU admission Non invasive ventilation NIV is considered a cornerstone management option in patients with acute exacerbation of COPD AECOPD Therefore early prediction of NIV failure may help in decision making regarding escalation to invasive mechanical ventilation To date the diaphragm is the main respiratory muscle and derangement of its function is an important factor in the pathophysiology of COPD COPD patients have increased airway resistance and airflow limitation which in turn increases the mechanical load of breathing exerted on the diaphragm Diaphragmatic weakness in COPD patients results from decreased muscle strength and mobility Although diaphragmatic performance is a key determinant of dyspnea in COPD patients it is rarely assessed in clinical practice In practice only vital sign such as respiratory rate and arterial blood gases parameters ABG such as PH PaO2 PaCO2 SPO2 and fiO2paO2 are considered predictors of NIV outcome
Assessment of diaphragmatic function transthoracic ultrasound TUS is a reliable safe and bed side method for prediction of NIV outcome Several tools commonly applied to determine diaphragmatic function such as fluoroscopy Computed tomography CT transdiaphragmatic pressure measurement phrenic nerve stimulation and electromyography cant be routinely used in intensive care units due to technical challenges and limitations
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None