Ignite Creation Date:
2024-05-06 @ 7:49 PM
Last Modification Date:
2024-10-26 @ 3:14 PM
Study NCT ID:
NCT06144762
Status:
RECRUITING
Last Update Posted:
2024-01-02
First Post:
2023-11-13
Brief Title:
Precision Imaging for Early Detection and Targeted Treatment Monitoring in Pancreatic Cancer
Sponsor:
Institut du Cancer de Montpellier - Val dAurelle
Organization:
Institut du Cancer de Montpellier - Val dAurelle
Study Overview
Official Title:
Precision Imaging for Early Detection and Targeted Treatment Monitoring in Pancreatic Cancer
Status:
RECRUITING
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PANC-O-MICS
Brief Summary:
Specifically in this project the objective will be developped a model to capture imaging-based tumor heterogeneity with multiscale radiomics approach by obtaining the mirror tumor image at in vivo MRI ex vivo MRI at histology This imaging model giving a perfect virtual histology tumor representation will be secondary implemented on routine in vivo clinical MRI for early cancer detection and treatment monitoring Successful completion of this proposal will lead to a comprehensive non invasive characterisation of pancreatic cancer and will be a game changer in patient management
Detailed Description:
With a five-year survival rate of only 3 for the majority of patients pancreatic cancer is a global healthcare challenge By the time of diagnosis over half of pancreatic cancers are metastasized The dire disease situation reflects our inability to diagnose pancreatic cancer early and to effectively treat it Our failure to diagnose the disease early results in part from the inaccessibility of the organ difficulties in detecting small pancreatic lesions by conventional imaging approaches and a poor understanding of the spectrum of heterogeneity in pancreatic cancer Single time point single site biopsies cannot assess entire tumor while multiple biopsies at several time points are not feasible in clinical routine Limitations of invasive sampling may be addressed with non-invasive imaging that captures morphologic and functional information about the entire tumor in space and if repeated in time Radiomics has the potential for whole tumour virtual sampling using a single or serial non-invasive examinations in place of biopsies By approaching images as data able to be mined instead of merely pictures in conventional radiology quantitative imaging allows for further information to be extracted from medical images as well as for global assessments across large patient populations Therefore these new quantitative approaches hold the promise of detecting pancreatic cancer characteristics that the naked eye alone cannot perceive from conventional medical imaging opening new doors for personalized medicine in pancreatic cancer To date no study has evaluated the value of radiomics at macroscopic in vivo 15T3TMRI and microscopic ex vivo 94TMRI scale for early cancer detection and targeted treatment monitoring Specifically in this project the objective will be developpe a model to capture imaging-based tumor heterogeneity with multiscale radiomics approach by obtaining the mirror tumor image at in vivo MRI ex vivo MRI at histology This imaging model giving a perfect virtual histology tumor representation will be secondary implemented on routine in vivo clinical MRI for early cancer detection and treatment monitoring Successful completion of this proposal will lead to a comprehensive non invasive characterisation of pancreatic cancer and will be a game changer in patient management
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None