Ignite Creation Date:
2024-05-06 @ 7:48 PM
Last Modification Date:
2024-10-26 @ 3:14 PM
Study NCT ID:
NCT06143800
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-11-22
First Post:
2023-10-31
Brief Title:
Reconsolidation-Based Intervention for Traumatic Memories
Sponsor:
Shenzhen Kangning Hospital
Organization:
Shenzhen Kangning Hospital
Study Overview
Official Title:
The Effect and Underlying Mechanism of Reconsolidation-Based Cognitive Reappraisal for Traumatic Memories in Patients With Major Depression Disorder
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this clinical trial is to test the effect and underlying mechanism of reconsolidation-based cognitive reappraisal for traumatic memories in patients with major depression disorder The main questions it aims to answer are
Is cognitive reappraisal based on memory reconsolidation effective for laboratory-created traumatic memories Which of the two classical cognitive reassessment schemes is more effective
What is the neural mechanism by which the novel cognitive reappraisal based on memory reconsolidation alters traumatic memories
Can repeated use of the novel cognitive reappraisal based on memory reconsolidation alter the actual childhood traumatic memories of patients with major depression disorder Can it reduce depressive symptoms Are the effects long-lasting Participants will be grouped to receive the intervention retrieval cognitive reappraisal non-retrieval cognitive reappraisal The researchers will compare the differences in long-term memory tests and the improvement in depressive symptoms between the two groups to see the effects of the memory-based reconsolidation intervention
Is cognitive reappraisal based on memory reconsolidation effective for laboratory-created traumatic memories Which of the two classical cognitive reassessment schemes is more effective
What is the neural mechanism by which the novel cognitive reappraisal based on memory reconsolidation alters traumatic memories
Can repeated use of the novel cognitive reappraisal based on memory reconsolidation alter the actual childhood traumatic memories of patients with major depression disorder Can it reduce depressive symptoms Are the effects long-lasting Participants will be grouped to receive the intervention retrieval cognitive reappraisal non-retrieval cognitive reappraisal The researchers will compare the differences in long-term memory tests and the improvement in depressive symptoms between the two groups to see the effects of the memory-based reconsolidation intervention
Detailed Description:
There are three sub-trials in this study Participants in the first trial will learn the fear of emotional faces based on the Pavlovian conditioned fear learning paradigm Using an inter-subject experimental design the intervention will be divided into four groups retrieval non-retrieval self-concerned cognitive reappraisalcontext-concerned cognitive reappraisal The researchers will compare the differences between the four groups on long-term memory tests to see if the cognitive reappraisal based on memory reconsolidation has effect on traumatic memory in the laboratory of depressed patients
Participants in the second trial are given the same treatment as in the first but with brain imaging equipment to gain brain imaging data The researchers will compare the brain functional characteristics of the four groups in the long-term memory test in order to explore the neural mechanism of the effect of cognitive reappraisal on traumatic memory intervention based on memory reconsolidation mechanism
Participants in the third trial are divided into two groups retrieval cognitive reappraisal and non-retrieval cognitive reappraisal for an eight-week intervention Finally the researchers will compare the improvement in depressive symptoms between the two groups and retest physiological arousal and subjective assessments of traumatic memories one year later to see the long-term effects of the memory-based reconsolidation intervention
Participants in the second trial are given the same treatment as in the first but with brain imaging equipment to gain brain imaging data The researchers will compare the brain functional characteristics of the four groups in the long-term memory test in order to explore the neural mechanism of the effect of cognitive reappraisal on traumatic memory intervention based on memory reconsolidation mechanism
Participants in the third trial are divided into two groups retrieval cognitive reappraisal and non-retrieval cognitive reappraisal for an eight-week intervention Finally the researchers will compare the improvement in depressive symptoms between the two groups and retest physiological arousal and subjective assessments of traumatic memories one year later to see the long-term effects of the memory-based reconsolidation intervention
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None