Ignite Creation Date:
2024-05-06 @ 7:48 PM
Last Modification Date:
2024-10-26 @ 3:14 PM
Study NCT ID:
NCT06144255
Status:
COMPLETED
Last Update Posted:
2024-03-21
First Post:
2023-11-16
Brief Title:
Dose-Dependent Effect of Intranasal Insulin in Humans Using Functional Magnetic Resonance Imaging fMRI
Sponsor:
Florian Schmitzberger
Organization:
University of Michigan
Study Overview
Official Title:
Phase 1 Dose-Dependent Effect of Intranasal Insulin in Humans Using Functional MRI
Status:
COMPLETED
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this trial is to study the brain response using functional MRI fMRI before and after varying doses of insulin given through the nose The magnetic resonance imaging uses a very strong magnet to produce images of participants brain It becomes a functional MRI when the study team looks at the activity within the brain blood flow change in metabolism
Detailed Description:
If cardiac arrest is not treated immediately it causes sudden death Intranasal insulin may be a way to prevent the brain injury that occurs after a cardiac arrest or other brain injury Even when immediate treatment gets the heart beating again many victims remain comatose and die later from brain injury Nasal insulin reduces brain injury in animal experiments and has been used to try to improve brain degeneration in patients with Alzheimers disease in doses up to 160 units
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None