Ignite Creation Date:
2024-05-06 @ 7:48 PM
Last Modification Date:
2024-10-26 @ 3:14 PM
Study NCT ID:
NCT06147700
Status:
RECRUITING
Last Update Posted:
2023-11-28
First Post:
2023-09-25
Brief Title:
Identifying Molecular Determinants of Infertility in Men MODIFY
Sponsor:
Singapore Institute for Clinical Sciences
Organization:
Singapore Institute for Clinical Sciences
Study Overview
Official Title:
Identifying Molecular Determinants of Infertility in Men MODIFY
Status:
RECRUITING
Status Verified Date:
2023-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to understand the underlying mechanisms of infertility caused by unknown factors The investigator propose to identify small non-coding RNA sncRNA biomarkers of infertility and advance towards developing a more accurate and robust approach for infertility diagnosis
Detailed Description:
The goal of the study is to identify small non-coding RNA signatures of infertility in men through the comparison of sperm sncRNA profiles from around 100 men 21-50 years of age The participants will be classified into fertile and infertile groups by the conventional method
Through the project the investigator intends to understand the underlying mechanisms of idiopathic infertility By utilizing semen as liquid biopsy through sperm sncRNA profiling and comparison infertile vs fertile The investigator proposes to identify the sncRNA miRNAs piRNAs and tRFs as biomarkers of infertility
The investigator proposes to generate a validated signature of sncRNAs that will help in selecting high quality sperms for IVF
Through the project the investigator intends to understand the underlying mechanisms of idiopathic infertility By utilizing semen as liquid biopsy through sperm sncRNA profiling and comparison infertile vs fertile The investigator proposes to identify the sncRNA miRNAs piRNAs and tRFs as biomarkers of infertility
The investigator proposes to generate a validated signature of sncRNAs that will help in selecting high quality sperms for IVF
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None