Ignite Creation Date:
2024-05-06 @ 7:47 PM
Last Modification Date:
2024-10-26 @ 3:14 PM
Study NCT ID:
NCT06136247
Status:
RECRUITING
Last Update Posted:
2023-11-18
First Post:
2023-11-01
Brief Title:
Integrating Brain Neurocognitive and Computational Tools in OUD
Sponsor:
University of Pennsylvania
Organization:
University of Pennsylvania
Study Overview
Official Title:
Integrating Brain Neurocognitive and Computational Tools in Opioid Use Disorder OUD to Characterize Executive Function and to Predict Clinical Outcomes
Status:
RECRUITING
Status Verified Date:
2023-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The 5-year K01 Mentored Research Scientist proposal will employ brain neurocognitive and computational tools eg machine learning to understand the impact of opioid-use disorder OUD and common co-occurring issues on executive function and clinical outcomes There have been record numbers of fatal and non-fatal overdoses ODs associated with opioids and other drugs in the past 12-months Improving classification and predictive capabilities to enhance treatment and prevent relapse is of the upmost importance Deficits in neurocognition often are associated with poor treatment outcomes eg more drug use medication non-adherence yet co-occurring issues associated with OUD eg depression anxiety physicalsexual abuse neglect make it difficult to parse which contributing factors lead to worse executive function EF and poorer treatment outcomes Novel brain neurocognitive and computational tools are needed to help determine these differences in order to lay the foundation for better treatments This need has shaped both the training plan and the associated research project in a 5-year K01 Mentored Research Scientist proposal building on Dr Regiers prior preclinical and clinical addiction neuroscience experience focused mostly on cocaine-use disorders cue-reactivity subcortical networks prior adversity and univariate imaging techniques
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None