Ignite Creation Date:
2024-05-06 @ 7:45 PM
Last Modification Date:
2024-10-26 @ 3:13 PM
Study NCT ID:
NCT06125275
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-11-09
First Post:
2023-11-06
Brief Title:
Pattern of Acute Antipsychotic Drug- Toxicity in Children
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Pattern of Acute Antipsychotic Drug- Toxicity in Children at Assiut University Children Hospital
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Pattern of Acute Antipsychotic Drug- Toxicity in Children at Assiut University Children Hospital
Determine the pattern and outcome of acute antipsychotic drug- toxicity of children who are admitted to The emergency department of Assiut University Children Hospital AUCH
Estimate prevalence of acute antipsychotics drug-toxicity in children and adolescents at AUCH
Determine the pattern and outcome of acute antipsychotic drug- toxicity of children who are admitted to The emergency department of Assiut University Children Hospital AUCH
Estimate prevalence of acute antipsychotics drug-toxicity in children and adolescents at AUCH
Detailed Description:
Acute poisoning in pediatrics is very common as it is one of the prominent causes of mortality and morbidity worldwide as children are curious and they explore at home and around Acute poisoning has also been the 3rd most common treated injury for children less than 16 years in the emergency units Accidental ingestion is one of the most important causes of poisoning in children and is most prevalent between 1-5 year olds During adolescence medications used for committing suicide are the main cause of poisoning
Drug ingestion is the commonest cause of acute poisoning among children according to poison control centers records all over the world A great percent of hospital admission cases involves drug poisoning particularly with psychotropic drugs such as sedatives antidepressants and neuroleptics
Antipsychotics are primary used to treat agitated behavior various neurological conditions motor tics chorea and dystoniaschizophrenia manic phase of bipolar disorders however they are often used to treat nausea vomiting and headache Antipsychotics toxic effects include anticholinergic and extrapyramidal syndromes as well as CNS and cardiovascular depression
Antipsychotics are classified as typical or atypical They are also classified by their chemical structure as first-generation including butyrophenones droperidol haloperidol and phenothiazines chlorpromazine promethazine and second generation such as olanzapine risperidone quetiapine and more recently ziprasidone and aripiprazole
Second-generation antipsychotics or atypical antipsychotics were introduced in 1989 and were anticipated to be equally effective for treatment of psychosisThey also had the advertised advantage of fewer extrapyramidal side effects such as dystonias akathisia parkinsonism and tardive dyskinesia at therapeutic dosing
These medications are now first-line therapy in the treatment of schizophrenia and are additionally being used in a wide array of conditions in both adults and children including bipolar disorder tic disorders eating disorders obsessive-compulsive disorder and developmental disorders such as autism Risperidone and aripiprazole were approved by the FDA in 2006 and 2009 respectively to treat irritability associated with Autism spectrum disorder ASD
Antipsychotics overdose is common in Western society In 2010 poison control centers in the US received about 43 000 calls complaining of atypical antipsychotics overdose The actual incidence of atypical antipsychotics overdose is greater than announced due to underreporting Overdose of an atypical antipsychotic is presented clinically with multiple disorders as CNS depression tachycardia and orthostatic hypotension
Supportive measures as maintaining patent airway assessment of breathing maintaining adequate circulation are necessary before confirmation of intoxication Evaluation and management of antipsychotic drugs toxicities needs high level of suspicion careful history taking proper examination and investigations to improve the outcome of such patients
Drug ingestion is the commonest cause of acute poisoning among children according to poison control centers records all over the world A great percent of hospital admission cases involves drug poisoning particularly with psychotropic drugs such as sedatives antidepressants and neuroleptics
Antipsychotics are primary used to treat agitated behavior various neurological conditions motor tics chorea and dystoniaschizophrenia manic phase of bipolar disorders however they are often used to treat nausea vomiting and headache Antipsychotics toxic effects include anticholinergic and extrapyramidal syndromes as well as CNS and cardiovascular depression
Antipsychotics are classified as typical or atypical They are also classified by their chemical structure as first-generation including butyrophenones droperidol haloperidol and phenothiazines chlorpromazine promethazine and second generation such as olanzapine risperidone quetiapine and more recently ziprasidone and aripiprazole
Second-generation antipsychotics or atypical antipsychotics were introduced in 1989 and were anticipated to be equally effective for treatment of psychosisThey also had the advertised advantage of fewer extrapyramidal side effects such as dystonias akathisia parkinsonism and tardive dyskinesia at therapeutic dosing
These medications are now first-line therapy in the treatment of schizophrenia and are additionally being used in a wide array of conditions in both adults and children including bipolar disorder tic disorders eating disorders obsessive-compulsive disorder and developmental disorders such as autism Risperidone and aripiprazole were approved by the FDA in 2006 and 2009 respectively to treat irritability associated with Autism spectrum disorder ASD
Antipsychotics overdose is common in Western society In 2010 poison control centers in the US received about 43 000 calls complaining of atypical antipsychotics overdose The actual incidence of atypical antipsychotics overdose is greater than announced due to underreporting Overdose of an atypical antipsychotic is presented clinically with multiple disorders as CNS depression tachycardia and orthostatic hypotension
Supportive measures as maintaining patent airway assessment of breathing maintaining adequate circulation are necessary before confirmation of intoxication Evaluation and management of antipsychotic drugs toxicities needs high level of suspicion careful history taking proper examination and investigations to improve the outcome of such patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None