Ignite Creation Date:
2024-05-06 @ 7:43 PM
Last Modification Date:
2024-10-26 @ 3:12 PM
Study NCT ID:
NCT06116851
Status:
RECRUITING
Last Update Posted:
2023-11-03
First Post:
2023-04-14
Brief Title:
Prostate Metabolism Cancer Risk and Gut Microbiota
Sponsor:
Turku University Hospital
Organization:
Turku University Hospital
Study Overview
Official Title:
Prostate Metabolism Cancer Risk and Gut Microbiota
Status:
RECRUITING
Status Verified Date:
2023-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PROMIC
Brief Summary:
This is a prospective single center translational multiple cohort study to investigate the association of gut microbiota and prostate cancer
Detailed Description:
Prostate cancer PCa is a significant health care system challenge PCa is the most common male cancer in Finland and most western countries Interestingly although the incidence of indolent latent PCa is very similar throughout the globe there is a remarkable global age-adjusted incidence variation up to 40-fold difference between highest and lowest incidences
Epidemiological data suggest that aging in men is associated with neoplastic processes in the prostate but only a subset of men will develop a true malignancy potentially affecting their life-span or quality of life Genetic factors have a significant effect on PCa risk but very likely life-style eg diet and physical activity affect PCa risk as well but the mechanisms mediating protective or harmful effects of life-style remain unclear
Gut microbiota ie the collection of microbes colonizing the gastrointestinal tract has been acknowledged to play significant role in many metabolic pathways and pathogenetic processes in the human body Although there is some evidence suggesting that gut microbiota affects therapy responses especially androgen deprivation in PCa its potential role in prostate carcinogenesis is not well documented Our previous studies suggest that gut microbiota composition is different in men with and without PCa potentially contributing to the Pca risk and that changes in steroid hormone synthesis may be one mechanism how gut microbiota affects PCa risk
PROMIC is a prospective single center translational multiple cohort study to investigate the association of gut microbiota and PCa The main aim is to validate our preliminary findings of association between gut microbiota and PCa We also study metabolic characteristics in the gut systemic circulation and prostate tissue in men with different gut microbiota signatures The study is carried out in Turku University Hospital and University of Turku
Epidemiological data suggest that aging in men is associated with neoplastic processes in the prostate but only a subset of men will develop a true malignancy potentially affecting their life-span or quality of life Genetic factors have a significant effect on PCa risk but very likely life-style eg diet and physical activity affect PCa risk as well but the mechanisms mediating protective or harmful effects of life-style remain unclear
Gut microbiota ie the collection of microbes colonizing the gastrointestinal tract has been acknowledged to play significant role in many metabolic pathways and pathogenetic processes in the human body Although there is some evidence suggesting that gut microbiota affects therapy responses especially androgen deprivation in PCa its potential role in prostate carcinogenesis is not well documented Our previous studies suggest that gut microbiota composition is different in men with and without PCa potentially contributing to the Pca risk and that changes in steroid hormone synthesis may be one mechanism how gut microbiota affects PCa risk
PROMIC is a prospective single center translational multiple cohort study to investigate the association of gut microbiota and PCa The main aim is to validate our preliminary findings of association between gut microbiota and PCa We also study metabolic characteristics in the gut systemic circulation and prostate tissue in men with different gut microbiota signatures The study is carried out in Turku University Hospital and University of Turku
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None