Ignite Creation Date:
2024-05-06 @ 7:43 PM
Last Modification Date:
2024-10-26 @ 3:12 PM
Study NCT ID:
NCT06103578
Status:
COMPLETED
Last Update Posted:
2023-10-27
First Post:
2023-09-13
Brief Title:
Evaluation of SOST TWEAK RANKL OPG Levels in Smokers and Non-Smokers With Periodontitis
Sponsor:
Gazi University
Organization:
Gazi University
Study Overview
Official Title:
Evaluation of Gingival Crevicular Fluid and Saliva SOST and TWEAK Gingival Crevicular Fluid RANKL and OPG Levels in Smokers and Non-smokers With Periodontitis
Status:
COMPLETED
Status Verified Date:
2023-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Periodontitis is a chronic inflammatory disease with multifactorial etiology Although periodontal disease is initiated by pathogens within the biofilm layer disease development and tissue destruction occur as a result of the interaction of periodontal pathogens and the host immune response It has been determined in the literature that smoking has a significant negative effect on periodontal tissues and increases the risk of periodontitis by 2-5 times It has been shown that there is a relationship between smoking and the incidence and progression of periodontitis However the mechanisms by which this occurs have not been explained In this study the effect of smoking on the levels of sclerostin SOST tumor necrosis factor-like weak inducer of apoptosis TWEAK receptor activator of nuclear factor-kB ligand RANKL and osteoprotegerin OPG which are effective in bone metabolism in gingival crevicular fluid GCF and saliva will be evaluated Participants in the study were in accordance with the 2017 World Workshop on Classification of Periodontal and Peri-implant Diseases and Conditions criteria as a result of clinical evaluations systemically healthy non-smokers diagnosed with stage 2 3 andor 4 periodontitis Group 1 n26 systemically healthy diagnosed with stage 2 3 andor 4 periodontitis and smokers Group 2 n26 systemically and periodontally healthy non-smokers Group 3-Control Group n26 Clinical periodontal indixes will be obtained from participants meeting the inclusion criteria GCF and saliva samples will be collected The samples will be examined by ELISA test at Gazi University Faculty of Medicine Department of Immunology
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None