Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005186
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-05-25
Brief Title:
Epidemiology of Cardiovascular Diseases in The Elderly
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2005-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To identify and describe the distribution of risk factors for cardiovascular disease in a cohort of free-living elderly persons
Detailed Description:
BACKGROUND
Cardiovascular disease is the leading cause of mortality in older persons in the United States Nearly two-thirds of all deaths in men and women 65 years of age or older are due to some manifestation of cardiovascular disease Further cardiovascular disease is a major cause of disability in the elderly Although there is relatively extensive epidemiologic data on risk factors for cardiovascular disease in younger individuals particularly younger men in 1986 when the study was initiated relatively little information existed on the prevalence and antecedents of cardiovascular disease in men and women over 65 years of age Further the data that did exist tended to be contradictory From a public health perspective it was important to identify risk factors for cardiovascular disease in older individuals for several reasons The numbers and proportion of elderly persons in the US were growing and would continue to grow well into the next century This segment of our society which comprised 12 percent of the population in 1986 accounted for one third of our health care costs Older Americans will continue to make significant demands on the health care system in the coming decades The identification of risk factors for this major public health problem eg cardiovascular disease may lead to interventions which would improve the health of older Americans and thus benefit the entire society
Data for this project have been gathered since 1975 by the Dunedin Program a population-based geriatric health-screening program This Program was designed to screen persons 65 years of age or older for a wide variety of medical disorders It was situated in Dunedin Florida which is on the mid-west Gulf coast Each participant was seen at the clinic once a year The clinic visit consisted of registration a physical examination and questionnairemedication form Data were available on family history of illnesses illnesses of participant smoking history alcohol use emotional status coffee consumption dietary habits current symptoms social activities exercise attitudes towards health care height weight blood pressure carotid artery auscultation electrocardiogram lipid levels blood chemistries and blood counts diabetes urine samples and medication use In 1986 a total of 5085 persons had completed the first screening examination and 1540 had completed a full eight years of screening
DESIGN NARRATIVE
In the first phase follow-up time for each participant was computed and changes in risk factor status analyzed Cardiovascular disease incidence and mortality rates were calculated In the second phase incidence rates of cardiovascular disease were computed by category of risk factor level at baseline The relative risk of cardiovascular disease was calculated for each risk factor Multivariable analyses were carried out in the third phase Regression models were used to determine independent and interactive effects of the identified risk factors on the incidence of and mortality from cardiovascular disease
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Cardiovascular disease is the leading cause of mortality in older persons in the United States Nearly two-thirds of all deaths in men and women 65 years of age or older are due to some manifestation of cardiovascular disease Further cardiovascular disease is a major cause of disability in the elderly Although there is relatively extensive epidemiologic data on risk factors for cardiovascular disease in younger individuals particularly younger men in 1986 when the study was initiated relatively little information existed on the prevalence and antecedents of cardiovascular disease in men and women over 65 years of age Further the data that did exist tended to be contradictory From a public health perspective it was important to identify risk factors for cardiovascular disease in older individuals for several reasons The numbers and proportion of elderly persons in the US were growing and would continue to grow well into the next century This segment of our society which comprised 12 percent of the population in 1986 accounted for one third of our health care costs Older Americans will continue to make significant demands on the health care system in the coming decades The identification of risk factors for this major public health problem eg cardiovascular disease may lead to interventions which would improve the health of older Americans and thus benefit the entire society
Data for this project have been gathered since 1975 by the Dunedin Program a population-based geriatric health-screening program This Program was designed to screen persons 65 years of age or older for a wide variety of medical disorders It was situated in Dunedin Florida which is on the mid-west Gulf coast Each participant was seen at the clinic once a year The clinic visit consisted of registration a physical examination and questionnairemedication form Data were available on family history of illnesses illnesses of participant smoking history alcohol use emotional status coffee consumption dietary habits current symptoms social activities exercise attitudes towards health care height weight blood pressure carotid artery auscultation electrocardiogram lipid levels blood chemistries and blood counts diabetes urine samples and medication use In 1986 a total of 5085 persons had completed the first screening examination and 1540 had completed a full eight years of screening
DESIGN NARRATIVE
In the first phase follow-up time for each participant was computed and changes in risk factor status analyzed Cardiovascular disease incidence and mortality rates were calculated In the second phase incidence rates of cardiovascular disease were computed by category of risk factor level at baseline The relative risk of cardiovascular disease was calculated for each risk factor Multivariable analyses were carried out in the third phase Regression models were used to determine independent and interactive effects of the identified risk factors on the incidence of and mortality from cardiovascular disease
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R23HL038628 | NIH | None | httpsreporternihgovquickSearchR23HL038628 |