Ignite Creation Date:
2024-05-06 @ 7:42 PM
Last Modification Date:
2024-10-26 @ 3:12 PM
Study NCT ID:
NCT06105164
Status:
NOT_YET_RECRUITING
Last Update Posted:
2023-10-27
First Post:
2023-10-19
Brief Title:
Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans
Sponsor:
Brigham and Womens Hospital
Organization:
Brigham and Womens Hospital
Study Overview
Official Title:
Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study uses a noninvasive technique called transcranial magnetic stimulation TMS to study satiety in healthy individuals
TMS is a noninvasive way of stimulating the brain using a magnetic field to change activity in the brain The magnetic field is produced by a coil that is held next to the scalp In this study the investigators will be stimulating the brain to learn more about the role of the cerebellum in satiety
TMS is a noninvasive way of stimulating the brain using a magnetic field to change activity in the brain The magnetic field is produced by a coil that is held next to the scalp In this study the investigators will be stimulating the brain to learn more about the role of the cerebellum in satiety
Detailed Description:
The purpose of this study is to conduct a circuit manipulation experiment to test the hypothesis that targeting the cerebellum can alter activity in response to food cues to advance the understanding of the involvement of the cerebellar-striatal circuit in feeding behavior
Participants will undergo an initial screening session to complete informed consent and undergo baseline assessments including physical activity and food craving Participants will additionally undergo an MRI scan that includes structural and resting-state functional magnetic resonance imaging rsfMRI These rsfMRI imagines will be used to isolate individual resting state networks for targeting of rTMS modulation
Participants will then complete two separate testing sessions involving MRI imaging and food intake assessments before and after rTMS One visit will involve consumption of a filling meal the other visit will be completed following an overnight fast
Participants will undergo an initial screening session to complete informed consent and undergo baseline assessments including physical activity and food craving Participants will additionally undergo an MRI scan that includes structural and resting-state functional magnetic resonance imaging rsfMRI These rsfMRI imagines will be used to isolate individual resting state networks for targeting of rTMS modulation
Participants will then complete two separate testing sessions involving MRI imaging and food intake assessments before and after rTMS One visit will involve consumption of a filling meal the other visit will be completed following an overnight fast
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
True
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None